US 11,883,689 B2
Neuromodulation techniques
Christopher Michael Puleo, Niskayuna, NY (US); Lakshmi Sireesha Kaanumalle, Schenectady, NY (US); Victoria Eugenia Cotero, Troy, NY (US); and John Frederick Graf, Ballston Lake, NY (US)
Assigned to GE Precision Healthcare LLLC, Wauwatosa, WI (US)
Filed by GENERAL ELECTRIC COMPANY, Schenectady, NY (US)
Filed on Apr. 18, 2022, as Appl. No. 17/722,948.
Application 17/722,948 is a continuation of application No. 16/143,255, filed on Sep. 26, 2018, granted, now 11,318,330.
Prior Publication US 2022/0233888 A1, Jul. 28, 2022
Int. Cl. A61N 7/00 (2006.01); A61N 1/36 (2006.01); G01N 33/68 (2006.01)
CPC A61N 7/00 (2013.01) [A61N 1/36189 (2013.01); G01N 33/68 (2013.01); A61N 2007/0004 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system, comprising:
an energy application device configured to apply a first non-invasive ultrasound energy treatment to a region of interest of a subject according to a treatment protocol having a recovery period between subsequent energy treatments to the subject to cause a change in concentration of one or more molecules at a distal site in the subject; and
a controller comprising a memory, wherein the memory stores instructions for the treatment protocol that, when executed by the controller, cause the controller to:
receive one or more inputs indicative of respective concentrations of the one or more molecules at the distal site;
determine that at least one of the respective concentrations of the one or more molecules are not within a respective threshold range associated with the treatment protocol;
adjust a time of the recovery period in the treatment protocol stored in the memory before applying a second non-invasive ultrasound energy treatment to the region of interest in response to determining that the at least one of the respective concentrations of the one or more molecules are not within the respective threshold range; and
cause the energy application device to operate the treatment protocol to apply the second non-invasive ultrasound energy treatment after the adjusted time of the recovery period.