US 11,883,671 B2
Methods, systems, and apparatus for closed-loop neuromodulation
Nicholas Lachlan Opie, Parkville (AU); Thomas James Oxley, New York, NY (US); and Gil Simon Rind, Parkville (AU)
Assigned to Synchron Australia Pty Limited, Melbourne (AU); and The University of Melbourne, Melbourne (AU)
Filed by Synchron Australia Pty Limited, Melbourne (AU); and The University of Melbourne, The University of Melbourne (AU)
Filed on Aug. 10, 2021, as Appl. No. 17/398,854.
Application 17/398,854 is a continuation of application No. PCT/US2020/059509, filed on Nov. 6, 2020.
Claims priority of provisional application 63/062,633, filed on Aug. 7, 2020.
Claims priority of provisional application 62/932,906, filed on Nov. 8, 2019.
Prior Publication US 2021/0361950 A1, Nov. 25, 2021
Int. Cl. A61N 1/36 (2006.01); A61N 1/375 (2006.01); A61N 1/378 (2006.01)
CPC A61N 1/36189 (2013.01) [A61N 1/36053 (2013.01); A61N 1/36064 (2013.01); A61N 1/36175 (2013.01); A61N 1/3787 (2013.01); A61N 1/37514 (2017.08); A61N 1/37516 (2017.08)] 18 Claims
OG exemplary drawing
 
1. A method of treating epilepsy, comprising:
detecting, using a first electrode array, an electrophysiological signal of a subject, wherein the electrophysiological signal is a signal associated with or correlated with the onset of an epileptic seizure, wherein the first electrode array is coupled to a first endovascular carrier implanted within the subject, wherein the first endovascular carrier is a coiled microwire and wherein the first electrode array comprises electrodes arranged along a length of the coiled microwire;
analyzing the electrophysiological signal using a neuromodulation unit implanted within the subject and electrically coupled to the first electrode array; and
stimulating an intracorporeal target of the subject using a second electrode array in response to the electrophysiological signal detected, wherein the intracorporeal target is stimulated as part of a treatment for epilepsy, wherein the second electrode array is electrically coupled to the neuromodulation unit, wherein the second electrode array is coupled to a second endovascular carrier implanted within the subject, wherein the second endovascular carrier is implanted within the internal jugular vein superior to a jugular foramen of the subject.