US 11,883,630 B2
Event-triggered model predictive control for embedded artificial pancreas systems
Eyal Dassau, Acton, MA (US); Francis J. Doyle, III, Chestnut Hill, MA (US); Stamatina Zavitsanou, Cambridge, MA (US); and Ankush Chakrabarty, Boston, MA (US)
Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Appl. No. 16/314,737
Filed by PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US)
PCT Filed Jul. 6, 2017, PCT No. PCT/US2017/040835
§ 371(c)(1), (2) Date Jan. 2, 2019,
PCT Pub. No. WO2018/009614, PCT Pub. Date Jan. 11, 2018.
Claims priority of provisional application 62/508,526, filed on May 19, 2017.
Claims priority of provisional application 62/359,098, filed on Jul. 6, 2016.
Prior Publication US 2022/0257857 A1, Aug. 18, 2022
Int. Cl. A61M 5/172 (2006.01); G16H 20/17 (2018.01)
CPC A61M 5/1723 (2013.01) [G16H 20/17 (2018.01); A61M 2205/52 (2013.01); A61M 2230/201 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An artificial pancreas, comprising:
a glucose sensor configured to output glucose data related to a concentration of glucose in the bloodstream of a subject;
an insulin pump;
a memory containing machine readable medium comprising machine executable code having stored thereon instructions for performing a method of delivering insulin; and
a control system coupled to the memory comprising one or more processors, the control system configured to execute the machine executable code to cause the processor to:
store, in the memory, a control action for determining an amount of insulin to inject;
receive, from the glucose sensor, a set of glucose data;
process the set of glucose data to determine whether an update event is triggered;
update the control action to determine a first insulin dose value if the update event has been triggered;
determine a second insulin dose value if the update event has not been triggered, wherein the determination of the second value uses less power than the updating of the control action; and
send a command to the insulin pump to deliver an amount of insulin based on either the first insulin dose value determined by the updated control action or the second insulin dose value.