	US 11,883,555 B2
	Composition for hard tissue repair and kit for hard tissue repair
Shinya Aoki, Yokohama (JP); Kengo Goto, Ichihara (JP); Takashi Miura, Chiba (JP); Tetsuya Hamada, Ichihara (JP); and Ayako Bando, Chiba (JP)
Assigned to MITSUI CHEMICALS, INC., Tokyo (JP)
Appl. No. 16/499,799
Filed by Mitsui Chemicals, Inc., Tokyo (JP)
PCT Filed Mar. 29, 2018, PCT No. PCT/JP2018/013472 § 371(c)(1), (2) Date Sep. 30, 2019, PCT Pub. No. WO2018/181822, PCT Pub. Date Oct. 4, 2018.
Claims priority of application No. 2017-072726 (JP), filed on Mar. 31, 2017.
Prior Publication US 2020/0030485 A1, Jan. 30, 2020
Int. Cl. A61L 24/06 (2006.01); A61L 24/00 (2006.01); A61L 24/02 (2006.01)

CPC A61L 24/06 (2013.01) [A61L 24/001 (2013.01); A61L 24/02 (2013.01); A61L 2400/06 (2013.01); A61L 2430/02 (2013.01); A61L 2430/06 (2013.01)]

6 Claims

1. A composition for hard tissue repair comprising a monomer (A), a polymer (B), a polymerization initiator (C) and a contrast medium (X) having a volume mean particle diameter of 3 μm or more,

wherein the monomer (A) is a methyl methacrylate,

wherein the polymer (B) comprises:

a polymer powder (b1) having a specific surface area of 0.05 to 0.5 m²/g, and,

a polymer powder (b2) having a specific surface area of 0.51 to 1.2 m²/g and/or a polymer powder (b3) of particles having a specific surface area of 1.5 to 4.5 m²/g,

wherein the initiator (C) is a partially oxidized trialkylboron which contains ethanol but does not contain an aprotic solvent, and

wherein a volume mean particle diameter of all particles contained in the composition for hard tissue repair is 15 to 26 μm.