	US 11,883,540 B2
	Stimulus activated cork-shell capsules
Todd Hoare, Ancaster (CA); Jonathan Dorogin, Richmond Hill (CA); David Koff, Ancaster (CA); and Andrew Singh, Toronto (CA)
Assigned to McMaster University, Hamilton (CA)
Filed by McMaster University, Hamilton (CA)
Filed on May 14, 2021, as Appl. No. 17/320,446.
Claims priority of provisional application 63/025,553, filed on May 15, 2020.
Prior Publication US 2021/0353550 A1, Nov. 18, 2021
Int. Cl. A61K 9/50 (2006.01); A61K 9/00 (2006.01)

CPC A61K 9/5031 (2013.01) [A61K 9/0009 (2013.01); A61K 9/501 (2013.01)]

23 Claims

1. A core-shell particle, comprising

1) An outer shell comprising at least one first polymer; and

2) at least one particulate phase embedded and/or dispersed within the outer shell, wherein the particulate phase comprises at least one inorganic oxide, metal salt, polymer, organometallic compound or contrast agent, and wherein the at least one particulate phase is releasable from or perdurable within the outer shell to create a pore in the outer shell upon exposure to an external stimulus, and wherein the at least one particulate phase has a different mechanical index from the outer shell.