	US 11,883,511 B2
	Thickening silica as fluoride carrier for tailored delivery and slow release
Alan Ceresa, Therwil (CH); Michael Neumann, Therwil (CH); Madeleine Manns, Laufen (CH); Nathalie Coq-Bernard, Muespach le Haut (FR); Andre Brunella, Dornach (CH); Marian Holerca, Somerset, NJ (US); and Thomas Schollbach, Basel (CH)
Assigned to GABA International Holding GmbH, Therwil (CH)
Filed by GABA International Holding GmbH, Therwil (CH)
Filed on Dec. 3, 2020, as Appl. No. 17/247,199.
Claims priority of provisional application 62/947,265, filed on Dec. 12, 2019.
Prior Publication US 2021/0177712 A1, Jun. 17, 2021
Int. Cl. A61K 8/25 (2006.01); A61K 8/21 (2006.01); A61Q 11/00 (2006.01); A61K 8/02 (2006.01)

CPC A61K 8/02 (2013.01) [A61K 8/25 (2013.01); A61Q 11/00 (2013.01); A61K 2800/48 (2013.01)]

16 Claims

1. An oral care composition comprising an orally acceptable vehicle, a thickening silica and a fluoride ion source, wherein fluoride is absorbed on the thickening silica, wherein the thickening silica has a particle size distribution (D95) less than or equal to 7 μm and a BET surface area of greater than or equal to 150 m²/g, and wherein the pH of the composition is below 5.5;

wherein the thickening silica loaded with fluoride is made by mixing the thickening silica and the fluoride ion source in an aqueous solution at a pH below 5.5;

wherein the fluoride ion source is selected from sodium fluoride, stannous fluoride, potassium fluoride, sodium monofluorophosphate, amine fluoride, ammonium fluoride, and a combination thereof; and

wherein the release of fluoride plateaus at approximately 400 seconds when measured at 24° C.