US 11,883,482 B2
Recombinant nucleic acid of Seneca valley virus, recombinant vaccine strain and preparation method and use thereof
Haixue Zheng, Lanzhou (CN); Fan Yang, Lanzhou (CN); Zixiang Zhu, Lanzhou (CN); Weijun Cao, Lanzhou (CN); Hong Tian, Lanzhou (CN); Keshan Zhang, Lanzhou (CN); Ting Wei, Lanzhou (CN); Min Zheng, Lanzhou (CN); Wei Zhang, Lanzhou (CN); Wen Dang, Lanzhou (CN); Xusheng Ma, Lanzhou (CN); Dan Li, Lanzhou (CN); Yi Ru, Lanzhou (CN); Jijun He, Lanzhou (CN); Jianhong Guo, Lanzhou (CN); and Xiangtao Liu, Lanzhou (CN)
Assigned to Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Filed by Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou (CN)
Filed on May 24, 2021, as Appl. No. 17/328,135.
Claims priority of application No. 202010212460.6 (CN), filed on Mar. 24, 2020.
Prior Publication US 2022/0031832 A1, Feb. 3, 2022
Int. Cl. C12N 7/00 (2006.01); C12N 15/66 (2006.01); C12N 15/10 (2006.01); A61K 39/125 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/125 (2013.01) [C12N 15/102 (2013.01); C12N 15/66 (2013.01); A61K 2039/5252 (2013.01); A61K 2039/53 (2013.01); C12N 7/00 (2013.01); C12N 2770/32034 (2013.01)] 15 Claims
 
1. A recombinant nucleic acid of Seneca valley virus, wherein the sequence of the recombinant nucleic acid is a viral genome sequence obtained by performing deletion and mutation on 5′UTR gene sequence of the Seneca valley virus strain;
the nucleotide sequence of the 5′UTR gene after deletion and mutation on the 5′UTR gene sequence of the Seneca valley virus strain is set forth in SEQ ID NO:1; and
the Seneca valley virus strain is SW/FJ/001 strain.