US 11,883,468 B2
Compositions and methods to suppress tumor growth in bone, prevent cachectic muscle loss, and preserve skeletal integrity
John Chirgwin, Indianapolis, IN (US); and Attaya Suvannasankha, Indianapolis, IN (US)
Assigned to THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, Washington, DC (US)
Filed by United States Government As Represented By The Department of Veterans Affairs, Washington, DC (US)
Filed on Oct. 22, 2020, as Appl. No. 17/077,716.
Claims priority of provisional application 62/924,416, filed on Oct. 22, 2019.
Prior Publication US 2021/0113667 A1, Apr. 22, 2021
Int. Cl. A61K 38/29 (2006.01); A61P 35/04 (2006.01); A61K 45/06 (2006.01)
CPC A61K 38/29 (2013.01) [A61K 45/06 (2013.01); A61P 35/04 (2018.01)] 7 Claims
 
1. A method of decreasing cancer-related cachexia in a subject with bone cancer comprising administering to the subject a therapeutically effective amount of bPTH7-34DD, wherein the bPTH7-34DD blocks parathyroid hormone-related protein (PTHrP), wherein the therapeutically effective amount of bPTH7-34DD is administered subcutaneously, intramuscularly, or intravenously.