US 11,883,438 B2
Sperm activator and uses thereof
Tokunori Yamamoto, Nagoya (JP); Satoshi Suzuki, Nagoya (JP); Yasuhito Funahashi, Nagoya (JP); Yoshihisa Matsukawa, Nagoya (JP); Momokazu Gotoh, Nagoya (JP); Tomohiro Kitayama, Takayama (JP); Yoichiro Hoshino, Funai-gun (JP); and Tetsuma Murase, Gifu (JP)
Assigned to National University Corporation Nagoya University, Nagoya (JP); Gifu University, Gifu (JP); and Gifu Prefecture, Gifu (JP)
Appl. No. 16/327,817
Filed by National University Corporation Nagoya University, Nagoya (JP); Gifu University, Gifu (JP); and Gifu Prefecture, Gifu (JP)
PCT Filed Aug. 23, 2017, PCT No. PCT/JP2017/030204
§ 371(c)(1), (2) Date Feb. 23, 2019,
PCT Pub. No. WO2018/038180, PCT Pub. Date Mar. 1, 2018.
Claims priority of application No. 2016-164159 (JP), filed on Aug. 24, 2016.
Prior Publication US 2019/0240260 A1, Aug. 8, 2019
Int. Cl. A61K 35/50 (2015.01); A61K 35/51 (2015.01); A61K 35/52 (2015.01); A61P 15/08 (2006.01); A61K 35/32 (2015.01); A61K 35/54 (2015.01); A61K 35/28 (2015.01); A61K 35/35 (2015.01); A61D 19/00 (2006.01); A61D 19/02 (2006.01); A61K 35/00 (2006.01); C12N 5/076 (2010.01); C12N 5/0775 (2010.01)
CPC A61K 35/50 (2013.01) [A61D 19/00 (2013.01); A61D 19/02 (2013.01); A61K 35/00 (2013.01); A61K 35/28 (2013.01); A61K 35/32 (2013.01); A61K 35/35 (2013.01); A61K 35/51 (2013.01); A61K 35/52 (2013.01); A61K 35/54 (2013.01); A61P 15/08 (2018.01); C12N 5/061 (2013.01); C12N 5/0664 (2013.01); C12N 5/0665 (2013.01); C12N 5/0667 (2013.01); C12N 2500/80 (2013.01)] 8 Claims
 
1. A preparation for artificial insemination, comprising a sperm activator and semen, wherein the sperm activator's active ingredient is a filtrate obtained by filtering a disrupted product of one or more cells selected from the group consisting of adipose tissue-derived stem cells, dental pulp-derived stem cells, bone marrow-derived stem cells, and umbilical cord blood-derived stem cells.