	US 11,883,433 B1
	Chimeric antigen receptor comprising anti-mesothelin scFv, and use thereof
Jae Hyung An, Seongnam-si (KR); and Na Kyung Han, Seoul (KR)
Assigned to CELLENGENE INC., Seongnam-si (KR)
Appl. No. 18/255,814
Filed by CELLENGENE INC., Seongnam-si (KR)
PCT Filed May 25, 2022, PCT No. PCT/KR2022/007425 § 371(c)(1), (2) Date Jun. 2, 2023, PCT Pub. No. WO2022/250450, PCT Pub. Date Dec. 1, 2022.
Claims priority of application No. 10-2021-0067904 (KR), filed on May 26, 2021.
Int. Cl. C07K 16/30 (2006.01); A61K 39/395 (2006.01); A61K 35/17 (2015.01); C07K 16/18 (2006.01); A61P 35/00 (2006.01); C12N 5/0783 (2010.01); C12N 15/86 (2006.01); C12N 15/13 (2006.01); C12N 15/62 (2006.01); C07K 14/47 (2006.01); A61K 39/00 (2006.01)

CPC A61K 35/17 (2013.01) [A61K 39/4631 (2023.05); A61P 35/00 (2018.01); C07K 14/47 (2013.01); C07K 16/30 (2013.01); A61K 2039/505 (2013.01); A61K 2239/21 (2023.05); C12N 5/0638 (2013.01); C12N 15/62 (2013.01); C12N 15/86 (2013.01)]

16 Claims

1. An anti-mesothelin antibody or an antigen-binding fragment thereof, comprising:

a heavy chain variable region comprising a heavy chain CDR1 comprising an amino acid sequence consisting of SEQ ID NO: 1; a heavy chain CDR2 comprising an amino acid sequence consisting of SEQ ID NO: 2; and a heavy chain CDR3 comprising an amino acid sequence consisting of SEQ ID NO: 3; and

a light chain variable region comprising a light chain CDR1 comprising an amino acid sequence consisting of SEQ ID NO: 4; light chain CDR2 comprising an amino acid sequence consisting of SEQ ID NO: 5; and a light chain CDR3 comprising an amino acid sequence consisting of SEQ ID NO: 6.