US 11,883,406 B2
Method for producing alginic acid-folic acid conjugate, alginic acid-folic acid conjugate produced thereby and pharmaceutical composition containing the same
Kang Won Lee, Suwon-si (KR); and Sa Ra Lee, Suwon-si (KR)
Assigned to SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul (KR)
Filed by SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul (KR)
Filed on Feb. 1, 2022, as Appl. No. 17/590,217.
Claims priority of application No. 10-2021-0014488 (KR), filed on Feb. 2, 2021.
Prior Publication US 2022/0241283 A1, Aug. 4, 2022
Int. Cl. A61K 31/519 (2006.01); A61K 47/61 (2017.01); A61P 35/00 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 47/61 (2017.08); A61P 35/00 (2018.01)] 10 Claims
 
1. An alginic acid-folic acid conjugate in which a carboxyl group of folic acid is linked to a hydroxyl group of alginic acid via an ester bond, or a pharmaceutically acceptable salt thereof, wherein the alginic acid-folic acid conjugate is represented by the following Formula 1:

OG Complex Work Unit Chemistry
wherein R is an alginic acid unit or an alginic acid polymer.