US 11,883,395 B2
Method of treating severe acute respiratory syndrome (SARS) virus infection by administering a protein disulfide isomerase (PDI) inhibitor
Vikas Anathy, Essex Junction, VT (US); Nicolas Chamberlain, Burlington, VT (US); and Amit Kumar, Burlington, VT (US)
Assigned to The University of Vermont and State Agricultural College, Burlington, VT (US)
Filed by The University of Vermont and State Agricultural College, Burlington, VT (US)
Filed on May 13, 2021, as Appl. No. 17/320,069.
Claims priority of provisional application 63/024,945, filed on May 14, 2020.
Prior Publication US 2021/0353620 A1, Nov. 18, 2021
Int. Cl. A61K 31/496 (2006.01); C07K 16/40 (2006.01); A61K 31/381 (2006.01); A61K 31/427 (2006.01); A61K 31/675 (2006.01); A61K 31/7068 (2006.01); A61K 39/395 (2006.01); A61K 31/4965 (2006.01); A61K 31/7048 (2006.01); C12N 15/113 (2010.01); A61K 35/16 (2015.01); A61K 39/42 (2006.01); A61P 31/14 (2006.01); G01N 33/50 (2006.01)
CPC A61K 31/496 (2013.01) [A61K 31/381 (2013.01); A61K 31/427 (2013.01); A61K 31/4965 (2013.01); A61K 31/675 (2013.01); A61K 31/7048 (2013.01); A61K 31/7068 (2013.01); A61K 35/16 (2013.01); A61K 39/3955 (2013.01); A61K 39/42 (2013.01); A61P 31/14 (2018.01); C07K 16/40 (2013.01); C12N 15/1137 (2013.01); G01N 33/5008 (2013.01); C12N 2310/14 (2013.01)] 19 Claims
 
1. A method of treating a severe acute respiratory syndrome (SARS) virus infection, the method comprising administering to a subject in need thereof, a composition comprising a protein disulfide isomerase (PDI) inhibitor and a pharmaceutically acceptable excipient.