US 11,883,384 B2
Substituted 2-aminobenzimidazoles analogs as antibiofilm agents
John Gunn, Columbus, OH (US); Laura Kuo, Columbus, OH (US); Christian Melander, Raleigh, NC (US); and William M. Huggins, Raleigh, NC (US)
Assigned to Ohio State Innovation Foundation, Columbus, OH (US); and North Carolina State University, Raleigh, NC (US)
Filed by Ohio State Innovation Foundation, Columbus, OH (US); and North Carolina State University, Raleigh, NC (US)
Filed on Jun. 16, 2022, as Appl. No. 17/841,938.
Application 17/841,938 is a division of application No. 17/044,517, abandoned, previously published as PCT/US2019/025683, filed on Apr. 3, 2019.
Claims priority of provisional application 62/651,829, filed on Apr. 3, 2018.
Prior Publication US 2023/0138583 A1, May 4, 2023
Int. Cl. A61K 31/4184 (2006.01)
CPC A61K 31/4184 (2013.01) 14 Claims
 
1. A method for inhibiting biofilm formation or dispersing a biofilm in a subject, wherein the subject has a Salmonella enterica infection, comprising the step of administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a compound having a structure represented by a formula:

OG Complex Work Unit Chemistry
wherein R1 is a structure represented by a formula:

OG Complex Work Unit Chemistry
wherein each of R10a, R10b, R10c, R10d, and R10e is independently selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, and C1-C6 haloalkyl, provided that at least one of R10a, R10b, R10c, R10d, and R10e is not hydrogen; and
n is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, and 12,
or a pharmaceutically acceptable salt thereof; and
a pharmaceutically acceptable carrier.