US 11,883,203 B2
Skull-mounted drug and pressure sensor
Yehoshua Shachar, Santa Monica, CA (US); Thomas Chen, La Canada, CA (US); Thomas J. Lobl, Valencia, CA (US); Jeffrey A. Brydle, Pasadena, CA (US); Juan R. Gonzalez, Arleta, CA (US); Virote Indravudh, Santa Clarita, CA (US); Christian Merot, Ventura, CA (US); Allan R. Schwartz, Thousand Oaks, CA (US); and Chad Srisathapat, Sun Valley, CA (US)
Assigned to Cognos Therapeutics Inc., Inglewood, CA (US)
Filed by Cognos Therapeutics Inc., Los Angeles, CA (US)
Filed on Feb. 28, 2020, as Appl. No. 16/805,308.
Application 16/805,308 is a division of application No. 15/594,251, filed on May 12, 2017, granted, now 10,786,155.
Claims priority of provisional application 62/336,446, filed on May 13, 2016.
Prior Publication US 2020/0196868 A1, Jun. 25, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 5/1459 (2006.01); A61B 5/03 (2006.01); A61M 5/142 (2006.01); A61M 27/00 (2006.01); A61M 5/14 (2006.01); A61B 5/01 (2006.01); A61M 1/00 (2006.01); A61B 90/00 (2016.01)
CPC A61B 5/6868 (2013.01) [A61B 5/0031 (2013.01); A61B 5/03 (2013.01); A61B 5/031 (2013.01); A61B 5/1459 (2013.01); A61B 5/4839 (2013.01); A61M 5/142 (2013.01); A61B 5/01 (2013.01); A61B 2090/064 (2016.02); A61B 2562/0233 (2013.01); A61M 1/60 (2021.05); A61M 5/14 (2013.01); A61M 27/006 (2013.01)] 3 Claims
OG exemplary drawing
 
1. An apparatus comprising:
an implantable skull-mounted drug and pressure sensor (SOS);
a metronomic biofeedback pump (MBP) electrically coupled to the SOS;
a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP,
where the SOS comprises:
an optical ventricular catheter comprising a drug delivery port and a CSF optical sensing chamber communicated with the sending and receiving optical fibers included in the drug delivery and communications catheter;
an LED bundle coupled to the optical ventricular catheter, the LED bundle comprising a plurality of LEDs which are each configured to measure at least one optical absorption profile of cerebrospinal fluid (CSF); and
a photodetector coupled to the optical ventricular catheter,
where the CSF optical sensing chamber is configured to receive light from the LED bundle and reflect it back to the photodetector, and
where the MBP includes a drug reservoir, a pump communicated to the drug reservoir, a first pressure sensor coupled to the pump, an optical source and sensor circuit coupled to the sending and receiving optical fibers, and a first microcontroller subsystem for controlling the pump and bidirectionally communicating with the first pressure sensor and pump and the optical source and sensor circuit,
where the SOS further comprises a second microcontroller subsystem for controlling the LED bundle and photodetector, wherein the second microcontroller subsystem communicates a measurement detected by the photodetector to the first microcontroller subsystem.