US 11,883,165 B2
Microfluidic systems for epidermal sampling and sensing
John A. Rogers, Wilmette, IL (US); Jungil Choi, Chicago, IL (US); Tyler R. Ray, Evanston, IL (US); Johnathan T. Reeder, Plano, TX (US); Yurina Sekine, Evanston, IL (US); Amay J. Bandodkar, Evanston, IL (US); Yi Zhang, Evanston, IL (US); Hexia Guo, Evanston, IL (US); Sungbong Kim, Champaign, IL (US); and Diana Ostojich, Evanston, IL (US)
Assigned to NORTHWESTERN UNIVERSITY, Evanston, IL (US); and THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US)
Filed by NORTHWESTERN UNIVERSITY, Evanston, IL (US); and THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US)
Filed on Sep. 22, 2020, as Appl. No. 17/027,887.
Application 17/027,887 is a continuation of application No. 16/616,770, granted, now 10,925,523, previously published as PCT/US2018/035661, filed on Jun. 1, 2018.
Claims priority of provisional application 62/514,546, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,374, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,559, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,455, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,436, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,489, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,515, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,520, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,468, filed on Jun. 2, 2017.
Prior Publication US 2021/0000395 A1, Jan. 7, 2021
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/053 (2021.01); A61B 5/103 (2006.01); A61B 5/1455 (2006.01); B01L 3/00 (2006.01)
CPC A61B 5/14539 (2013.01) [A61B 5/0002 (2013.01); A61B 5/053 (2013.01); A61B 5/1032 (2013.01); A61B 5/1455 (2013.01); A61B 5/14517 (2013.01); A61B 5/14546 (2013.01); A61B 5/4842 (2013.01); A61B 5/6806 (2013.01); B01L 3/502715 (2013.01); A61B 5/6833 (2013.01); A61B 2562/028 (2013.01); A61B 2562/164 (2013.01); B01L 2300/025 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/0803 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/123 (2013.01); B01L 2400/0406 (2013.01); B01L 2400/0688 (2013.01)] 28 Claims
OG exemplary drawing
 
1. A microfluidic system for measuring a characteristic of a biofluid, comprising:
a flexible substrate;
a collection layer embedded in or supported by the flexible substrate, wherein the collection layer is configured to promote transport of the biofluid from a skin surface;
at least one reservoir chamber embossed in the collection layer, the at least one reservoir chamber having:
an absorbent provided to receive at least a portion of the biofluid from the collection layer; and
a sensor for measuring the characteristic of the biofluid received by the absorbent; wherein the absorbent provides a force for transporting the biofluid that is greater than a capillary force of the collection layer for transporting the biofluid; and
a protective layer embedded in or supported by the flexible substrate, wherein the protective layer is configured to prevent the biofluid from escaping from the at least one reservoir chamber.