US 11,883,162 B2
System for predicting a patient's blood glucose level
Hector-Manuel Romero Ugalde, Grenoble (FR); Stéphane Bonnet, Grenoble (FR); and Eléonore Maeva Doron, La Tronche Grenoble (FR)
Assigned to Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Paris (FR)
Appl. No. 16/982,096
Filed by Commissariat à I'Énergie Atomique et aux Énergies Alternatives, Paris (FR)
PCT Filed Mar. 6, 2019, PCT No. PCT/FR2019/050505
§ 371(c)(1), (2) Date Sep. 18, 2020,
PCT Pub. No. WO2019/180341, PCT Pub. Date Sep. 26, 2019.
Claims priority of application No. 1852354 (FR), filed on Mar. 20, 2018.
Prior Publication US 2021/0100486 A1, Apr. 8, 2021
Int. Cl. A61M 5/172 (2006.01); A61B 5/145 (2006.01); A61B 5/11 (2006.01); A61B 5/00 (2006.01); A61M 5/142 (2006.01); A61B 5/024 (2006.01)
CPC A61B 5/14532 (2013.01) [A61B 5/024 (2013.01); A61B 5/1118 (2013.01); A61B 5/7275 (2013.01); A61B 5/746 (2013.01); A61M 5/14244 (2013.01); A61M 5/1723 (2013.01); A61M 2005/1726 (2013.01)] 12 Claims
OG exemplary drawing
 
1. An automated system for controlling a patient's blood glucose, comprising a processing and control unit configured to:
predict, based on a first mathematical model, a future trend of the patient's blood glucose over a prediction period, and
regulate, based on the prediction, insulin delivered to the patient, wherein the regulating comprises controlling an insulin injection device, wherein the first mathematical model takes as inputs:
a variable EE(t) representative of a time variation of the patient's energy expenditure;
a variable IOB(t) representative of a time variation of the patient's quantity of insulin on board; and
a variable COB(t) representative of a time variation of the patient's quantity of carbohydrate on board,
and wherein the first mathematical model is physiological model only defined by the observation of the effects of input variables EE(t), IOB(t) and COB(t) on the patient's blood glucose, without taking into account different known physiological mechanisms operating in the patient's body,
wherein, in operation, the processing and control unit receives a signal CHO(t), representative of a time variation of the quantity of carbohydrates ingested by the patient, and a signal I(t) representative of a time variation of the quantity of insulin injected to the patient, and wherein the processing and control unit is configured to calculate the input variables IOB(t) and COB(t) of the first mathematical model as follows:
IOB(t)=Σk=0KI(t−k)*hIOB(k) and
COB(t)=Σk=0KCHO(t−k)*hCOB(k),
where K is an integer greater than 1, k is an integer in the range from 0 to K, hIOB is an action function representing a time variation of an effect of the injected insulin on the absorption of blood glucose, and hCOB is an action function representing a time variation of an effect of the ingested carbohydrates on the blood glucose.