US 11,882,837 B2
Method and composition comprising detoxified lipopolysaccharide and lipoteichoic acid for preventing or inhibiting formation of biofilm
Kyu-Ho Lee, Seoul (KR); Hyo-Sun Kwak, Cheongju-si (KR); Youchul Jung, Gimhae-si (KR); Kyung Jo Lee, Seoul (KR); Jeong-A Kim, Seoul (KR); Boram Jang, Incheon (KR); and Sebin Kang, Gwacheon-si (KR)
Assigned to SOGANG UNIVERSITY RESEARCH & BUSINESS DEVELOPMENT FOUNDATION, Seoul (KR); and KOREA FOOD & DRUG ADMINISTRATION, Cheongju-si (KR)
Filed by SOGANG UNIVERSITY RESEARCH & BUSINESS DEVELOPMENT FOUNDATION, Seoul (KR); and KOREA FOOD & DRUG ADMINISTRATION, Cheongju-si (KR)
Filed on Sep. 20, 2019, as Appl. No. 16/577,944.
Claims priority of application No. 10-2018-0145153 (KR), filed on Nov. 22, 2018.
Prior Publication US 2020/0163341 A1, May 28, 2020
Int. Cl. A01N 63/10 (2020.01); A61L 2/00 (2006.01); A01N 1/00 (2006.01); A01N 63/20 (2020.01); A61K 35/66 (2015.01); A61K 35/74 (2015.01); A61K 36/00 (2006.01); A61P 31/04 (2006.01); C12N 1/20 (2006.01); C12P 39/00 (2006.01); C12R 1/01 (2006.01); C12R 1/025 (2006.01); C12N 1/00 (2006.01)
CPC A01N 63/10 (2020.01) [A01N 1/00 (2013.01); A01N 63/20 (2020.01); A61K 35/66 (2013.01); A61K 35/74 (2013.01); A61K 36/00 (2013.01); A61L 2/00 (2013.01); C12N 1/20 (2013.01); C12N 1/205 (2021.05); C12P 39/00 (2013.01); A61P 31/04 (2018.01); C12N 1/00 (2013.01); C12R 2001/01 (2021.05); C12R 2001/025 (2021.05)] 7 Claims
 
1. A method of inhibiting or preventing biofilm formation comprising contacting the composition with Gram-positive or Gram-negative bacteria, wherein the composition comprises dLPS (deacylated Lipopolysaccharide) and dLTA (deacylated Lipoteichoic acid) in combination, wherein the dLPS is from Bacteroides vulgatus MGM001 (Bacteroides vulgatus MGM001) strain deposited as KCTC13624BP at Korean Collection for Type Cultures.