	US 12,208,082 B1
	Method of treating middle east respiratory syndrome (MERS)
Ahmed Lafi Alaofi, Riyadh (SA); and Mudassar Ahmad Shahid, Riyadh (SA)
Assigned to KING SAUD UNIVERSITY, Riyadh (SA)
Filed by KING SAUD UNIVERSITY, Riyadh (SA)
Filed on May 3, 2024, as Appl. No. 18/654,709.
Int. Cl. A61K 31/353 (2006.01); A61P 31/14 (2006.01); C12N 9/99 (2006.01)

CPC A61K 31/353 (2013.01) [A61P 31/14 (2018.01); C12N 9/99 (2013.01)]

4 Claims

1. A method of inhibiting the activity of MERS-papain-like protease (PLpro), comprising:

administering a therapeutically effective amount of a pharmaceutical composition consisting of fisetin and a pharmaceutically acceptable carrier to a subject in need thereof; and

binding fisetin to the MERS-papain-like protease (PLpro).