US 11,879,837 B2
Wide area optical photothermal infrared spectroscopy
Craig Prater, Santa Barbara, CA (US); Derek Decker, Santa Barbara, CA (US); and Roshan Shetty, Westlake Village, CA (US)
Assigned to Photothermal Spectroscopy Corp., Santa Barbara, CA (US)
Appl. No. 17/250,124
Filed by Photothermal Spectroscopy Corp., Santa Barbara, CA (US)
PCT Filed May 31, 2019, PCT No. PCT/US2019/034944
§ 371(c)(1), (2) Date Dec. 1, 2020,
PCT Pub. No. WO2019/232399, PCT Pub. Date Dec. 5, 2019.
Claims priority of provisional application 62/679,588, filed on Jun. 1, 2018.
Prior Publication US 2021/0215601 A1, Jul. 15, 2021
Int. Cl. G01N 21/3563 (2014.01); G06T 7/00 (2017.01); G02B 21/06 (2006.01); G02B 21/36 (2006.01); C12M 1/00 (2006.01); C12M 1/26 (2006.01); C12M 1/34 (2006.01); C12M 1/36 (2006.01); C12N 1/12 (2006.01); H04N 23/74 (2023.01); H04N 23/741 (2023.01)
CPC G01N 21/3563 (2013.01) [C12M 21/02 (2013.01); C12M 29/00 (2013.01); C12M 29/04 (2013.01); C12M 29/22 (2013.01); C12M 33/00 (2013.01); C12M 39/00 (2013.01); C12M 41/12 (2013.01); C12M 41/26 (2013.01); C12M 41/34 (2013.01); C12M 41/36 (2013.01); C12M 41/44 (2013.01); C12M 41/48 (2013.01); C12N 1/12 (2013.01); G02B 21/06 (2013.01); G02B 21/365 (2013.01); G06T 7/97 (2017.01); H04N 23/74 (2023.01); H04N 23/741 (2023.01); G01N 2201/061 (2013.01); G01N 2201/062 (2013.01); G06T 2207/10048 (2013.01); G06T 2207/10056 (2013.01); G06T 2207/10152 (2013.01)] 32 Claims
OG exemplary drawing
 
1. An apparatus for microscopic analysis of a sample by simultaneously characterizing infrared absorption characteristics of a plurality of spatially resolved locations corresponding to a wide area of the sample, the apparatus comprising:
a source of infrared radiation configured to illuminate the wide area of the sample with a beam of infrared radiation;
a source of probe radiation configured to illuminate the wide area of the sample with a beam of probe radiation;
a collector configured to collect as collected probe radiation at least a portion of probe radiation from each of the plurality of spatially resolved locations on the sample;
at least one camera configured to detect at least a portion of the collected probe radiation to generate signals indicative of infrared absorption corresponding to each one of the plurality of spatially resolved locations,
wherein the signals indicative of infrared absorption have a spatial resolution of less than 1 micrometer.