US 11,879,034 B2
Functionalization of polymer scaffolds
Lonnie D. Shea, Ann Arbor, MI (US); Michael Skoumal, Ann Arbor, MI (US); and Ryan M. Pearson, Ann Arbor, MI (US)
Assigned to REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
Appl. No. 16/491,063
Filed by THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
PCT Filed Mar. 8, 2018, PCT No. PCT/US2018/021554
§ 371(c)(1), (2) Date Sep. 4, 2019,
PCT Pub. No. WO2018/165432, PCT Pub. Date Sep. 13, 2018.
Claims priority of provisional application 62/468,833, filed on Mar. 8, 2017.
Prior Publication US 2020/0010611 A1, Jan. 9, 2020
Int. Cl. A61K 47/50 (2017.01); A61K 47/64 (2017.01); C08G 63/91 (2006.01); A61K 47/59 (2017.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01); A61K 38/17 (2006.01)
CPC C08G 63/912 (2013.01) [A61K 38/177 (2013.01); A61K 47/545 (2017.08); A61K 47/593 (2017.08); A61K 47/64 (2017.08); A61K 47/6927 (2017.08)] 22 Claims
OG exemplary drawing
 
1. A polymer scaffold comprising:
a scaffold of a plurality of microparticles comprising a polymer modified to have a reactive handle, wherein the reactive handle is distributed homogeneously throughout the polymer scaffold, the reactive handle capable of reacting with a biomolecule to form a covalent or non-covalent bond between the biomolecule and the polymer scaffold, wherein the microparticles further comprise a second polymer and the second polymer is not modified with a reactive handle and the polymer modified to have a reactive handle and the second polymer are provided in a weight ratio of about 100:1 to 1:100; and
wherein the reactive handle is provided in an amount sufficient to bind the biomolecule in an amount sufficient to exert a bioactivity, and
wherein the microparticles are microspheres and the microspheres are arranged in a layer.