US 11,878,996 B2
Solid phase peptide synthesis processes and associated systems
Mark David Simon, Boston, MA (US); Bradley L. Pentelute, Cambridge, MA (US); Andrea Adamo, Cambridge, MA (US); Patrick Louis Heider, Midland, MI (US); and Klavs F. Jensen, Lexington, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
Filed on Dec. 18, 2020, as Appl. No. 17/127,951.
Application 17/127,951 is a continuation of application No. 15/695,795, filed on Sep. 5, 2017, granted, now 10,988,504.
Application 15/695,795 is a continuation of application No. 14/853,683, filed on Sep. 14, 2015, granted, now 9,868,759.
Application 14/853,683 is a continuation of application No. 13/833,745, filed on Mar. 15, 2013, granted, now 9,169,287.
Prior Publication US 2021/0188899 A1, Jun. 24, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 1/04 (2006.01); C07K 1/06 (2006.01); C07K 1/08 (2006.01); B01J 19/00 (2006.01); B01J 8/00 (2006.01)
CPC C07K 1/045 (2013.01) [B01J 8/00 (2013.01); B01J 19/00 (2013.01); B01J 19/0053 (2013.01); C07K 1/04 (2013.01); C07K 1/042 (2013.01); C07K 1/061 (2013.01); C07K 1/08 (2013.01)] 12 Claims
 
1. A process for adding amino acid residues to peptides, comprising:
flowing a first stream comprising amino acids and a second stream comprising an amino acid activating agent substantially simultaneously such that the first stream and the second stream are merged to form a mixed fluid stream comprising activated amino acids; and
flowing the mixed fluid stream into a reactor containing solid support on which peptides have been immobilized such that an activated amino acid is added to at least 99% of the immobilized peptides.