US 11,877,877 B2
Imaging system with adaptive object magnification
Ciaran Purdy, Tucson, AZ (US); Mikhail Viznyuk, Tucson, AZ (US); and Mehmet Akif Baysal, Tucson, AZ (US)
Assigned to Faxitron Bioptics, LLC, Marlborough, MA (US)
Filed by FAXITRON BIOPTICS, LLC, Marlborough, MA (US)
Filed on Apr. 4, 2022, as Appl. No. 17/712,376.
Application 17/712,376 is a continuation of application No. 16/646,379, granted, now 11,317,881, previously published as PCT/US2018/050490, filed on Sep. 11, 2018.
Claims priority of provisional application 62/556,566, filed on Sep. 11, 2017.
Prior Publication US 2022/0296189 A1, Sep. 22, 2022
Int. Cl. A61B 6/00 (2006.01); A61B 6/03 (2006.01)
CPC A61B 6/4411 (2013.01) [A61B 6/035 (2013.01); A61B 6/4452 (2013.01); A61B 6/5229 (2013.01)] 18 Claims
OG exemplary drawing
1. A method of imaging a tissue specimen in a cabinet including an x-ray source and an x-ray detector positioned along a first axis, the method comprising:
placing the tissue specimen on an object holder disposed within a chamber of the cabinet, the object holder being disposed at least partially between the x-ray source and the x-ray detector, wherein the object holder is selectively moveable in a direction along the first axis such that the object holder defines a first position;
determining a position of the tissue specimen at the first position of the object holder relative to the x-ray source and the first axis;
after the position of the tissue specimen at the first position is determined, moving the object holder within the chamber towards a second position based on the determined position of the tissue specimen;
rotating the object holder around a second axis perpendicular to the first axis, wherein the object holder rotates while in the second position;
simultaneously with rotating the object holder, emitting one or more x-ray beams along the first axis and through the tissue specimen;
generating a plurality of two-dimensional x-ray images of the tissue specimen; and
reconstructing the plurality of two-dimensional x-ray images into a three-dimensional data set of the tissue specimen.