US 12,203,928 B2
Methods and apparatus for detecting analytes
Omer Deutsch, Ofra (IL); Raluca Cohen, Jerusalem (IL); Yoav Neumann, Tzur Hadassah (IL); and Guy Krief, Jerusalem (IL)
Assigned to SALIGNOSTICS LTD, Jerusalem (IL)
Filed by SALIGNOSTICS LTD., Jerusalem (IL)
Filed on May 20, 2022, as Appl. No. 17/749,889.
Application 17/749,889 is a continuation of application No. 16/969,832, granted, now 11,360,084, previously published as PCT/IL2019/050171, filed on Feb. 13, 2019.
Claims priority of provisional application 62/630,516, filed on Feb. 14, 2018.
Prior Publication US 2022/0276240 A1, Sep. 1, 2022
Int. Cl. G01N 33/543 (2006.01); A61B 10/00 (2006.01); G01N 1/28 (2006.01); G01N 1/40 (2006.01); G01N 33/569 (2006.01)
CPC G01N 33/54306 (2013.01) [A61B 10/0051 (2013.01); G01N 1/28 (2013.01); G01N 1/286 (2013.01); G01N 1/405 (2013.01); G01N 33/56911 (2013.01); G01N 33/56961 (2013.01); G01N 2001/2826 (2013.01); G01N 1/4044 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method, comprising:
using:
an elongate barrel, the barrel shaped to define a channel therethrough, and having:
an opening into the channel at a proximal region of the barrel,
an outlet from the channel at a distal region of the barrel,
a porous carrier, disposed within the channel;
a reagent, held in the carrier; and
a lateral flow platform, coupled to the distal region of the barrel such that a sample pad of the lateral flow platform is in fluid communication with the outlet:
introducing a sponge holding a sample of a body fluid, the sponge coupled to a distal portion of a plunger, into the opening of the channel; and
sliding the distal portion of the plunger distally through the channel, thereby compressing the sponge within the channel, driving the sample:
out of the sponge and through the carrier, dissolving at least some of the reagent, and
with the dissolved reagent, through the outlet, and onto the sample pad of the lateral flow platform.