	US 12,203,110 B2
	RNA-programmable endonuclease systems and uses thereof
Andre Cohnen, Titz-Hasselsweiler (DE); Moritz Schmidt, Cologne (DE); Wayne Coco, Pulheim (DE); Michael Biag Gamalinda, Leverkusen (DE); Ashish Gupta, Leverkusen (DE); Christian Pitzler, Leverkusen (DE); Florian Richter, Leverkusen (DE); Jan Tebbe, Leverkusen (DE); Christopher Cheng, Cambridge, MA (US); Ryo Takeuchi, Cambridge, MA (US); and Caroline W. Reiss, Cambridge, MA (US)
Assigned to CRISPR THERAPEUTICS AG, Zug (CH); and BAYER HEALTHCARE LLC, Whippany, NJ (US)
Appl. No. 16/982,433
Filed by CRISPR THERAPEUTICS AG, Zug (CH); and BAYER HEALTHCARE LLC, Whippany, NJ (US)
PCT Filed Mar. 19, 2019, PCT No. PCT/US2019/023044 § 371(c)(1), (2) Date Sep. 18, 2020, PCT Pub. No. WO2019/183150, PCT Pub. Date Sep. 26, 2019.
Claims priority of provisional application 62/745,239, filed on Oct. 12, 2018.
Claims priority of provisional application 62/745,238, filed on Oct. 12, 2018.
Claims priority of provisional application 62/745,246, filed on Oct. 12, 2018.
Claims priority of provisional application 62/745,240, filed on Oct. 12, 2018.
Claims priority of application No. 18162681 (EP), filed on Mar. 19, 2018; application No. 18162683 (EP), filed on Mar. 19, 2018; application No. 18172625 (EP), filed on May 16, 2018; application No. 18174707 (EP), filed on May 29, 2018; and application No. 18181680 (EP), filed on Jul. 4, 2018.
Prior Publication US 2021/0054353 A1, Feb. 25, 2021
Int. Cl. C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/90 (2006.01)

CPC C12N 9/22 (2013.01) [C12N 15/11 (2013.01); C12N 15/113 (2013.01); C12N 15/907 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01)]

10 Claims

1. A synthetic RNA-guided nuclease (sRGN) polypeptide comprising an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 2.