	US 12,203,073 B2
	Plant viral RNA delivery nanoparticles and uses thereof
Nicole F. Steinmetz, San Diego, CA (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Dec. 21, 2020, as Appl. No. 17/129,463.
Claims priority of provisional application 62/951,143, filed on Dec. 20, 2019.
Prior Publication US 2021/0189396 A1, Jun. 24, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 21/04 (2006.01); A61K 45/06 (2006.01); A61K 47/62 (2017.01); A61K 47/69 (2017.01); C12N 7/00 (2006.01); C12N 15/113 (2010.01)

CPC C12N 15/1135 (2013.01) [A61K 45/06 (2013.01); A61K 47/62 (2017.08); A61K 47/6929 (2017.08); C12N 7/00 (2013.01); C12N 2310/14 (2013.01); C12N 2770/14023 (2013.01)]

11 Claims

1. A nanoparticle comprising a cowpea chlorotic mottle virus (CCMV); a siRNA; and an L17E M-lycotoxin peptide, wherein the siRNA is noncovalently loaded within the CCMV.