US 12,202,842 B2
MCL1 inhibitors
Hang Chu, San Mateo, CA (US); Juan A. Guerrero, Clayton, CA (US); Anna E. Hurtley, San Mateo, CA (US); Lan Jiang, Foster City, CA (US); Darryl Kato, San Francisco, CA (US); Tetsuya Kobayashi, Pleasanton, CA (US); David W. Lin, Berkeley, CA (US); Jonathan William Medley, San Bruno, CA (US); Devan Naduthambi, San Bruno, CA (US); Vickie H. Tsui, Burlingame, CA (US); Chandrasekar Venkataramani, San Carlos, CA (US); William J. Watkins, Saratoga, CA (US); Hong Yang, Fremont, CA (US); and Qingming Zhu, Walnut Creek, CA (US)
Assigned to Gilead Sciences, Inc., Foster City, CA (US)
Filed by Gilead Sciences, Inc., Foster City, CA (US)
Filed on Mar. 9, 2023, as Appl. No. 18/181,116.
Application 18/181,116 is a continuation of application No. 17/094,447, filed on Nov. 10, 2020, granted, now 11,667,652.
Claims priority of provisional application 62/934,400, filed on Nov. 12, 2019.
Prior Publication US 2023/0348494 A1, Nov. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 413/08 (2006.01); A61K 31/553 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07D 513/08 (2006.01); C07D 513/10 (2006.01); C07D 513/18 (2006.01); C07D 513/20 (2006.01); C07D 513/22 (2006.01); C07D 519/00 (2006.01); C07K 16/28 (2006.01)
CPC C07D 513/18 (2013.01) [A61K 45/06 (2013.01); C07D 513/08 (2013.01); C07D 513/20 (2013.01); C07D 513/22 (2013.01); C07D 519/00 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01)] 8 Claims
 
1. A compound of Formula (II):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein:
Z1 is selected from CR1a, or N;
Z2 is selected from CR2aR2b, S, NR2c, and O;
wherein each R1a, R2a, and R2b is independently selected from hydrogen, halo, C1-6alkyl, C1-6alkoxyl, C1-6haloalkyl, and C1-6haloalkoxyl; and
wherein R2c is independently selected from hydrogen, C1-6alkyl, and C1-6haloalkyl;
wherein R16 is 3-12 membered heterocyclyl or 5-12 membered heteroaryl; wherein R16 is optionally substituted with 1-5 RA;
R2 is selected from hydrogen, halo, C1-6alkyl, C1-6haloalkyl, C1-6alkoxyl, and —C1-4alkylene-O—C1-6alkyl;
R3 is selected from hydrogen, halo, C1-6alkyl, C1-6haloalkyl, C1-6alkoxyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, and —C1-4alkylene-O-5-10 membered heteroaryl; wherein each C1-6alkyl, C1-6haloalkyl, C1-6alkoxyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, and —C1-4alkylene-O-5-10 membered heteroaryl of R3 is optionally substituted with one to four groups independently selected from halo, C1-6alkyl, C1-6haloalkyl, and C1-6alkoxyl;
each R4 and R5 is independently selected from hydrogen, halo, hydroxyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C1-6alkoxyl, C1-6haloalkoxyl, —NRaaRbb, —NHC(O)—C1-6alkyl, —C(O)NH—C1-6alkyl, —O—C2-6alkynyl, —OC(O)—C1-6alkyl, —O—(CH2CH2O)n—C1-6alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C1-4alkylene-C3-10cycloalkyl, 5-10 membered heteroaryl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—5-10 membered heteroaryl, and —O—C1-4alkylene-5-10 membered heteroaryl;
wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C1-6alkoxyl, C1-6haloalkoxyl, —NHC(O)—C1-6alkyl, —C(O)NH—C1-6alkyl, —O—C2-6alkynyl, —OC(O)—C1-6alkyl, —O—(CH2CH2O)n—C1-6alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C1-4alkylene-C3-10cycloalkyl, 5-10 membered heteroaryl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—5-10 membered heteroaryl, and —O—C1-4alkylene-5-10 membered heteroaryl of R4 and R5 is optionally substituted with one to four groups independently selected from halo, hydroxyl, oxo, C1-6alkyl, C1-6alkoxyl, C1-6haloalkoxyl, —NRaaRbb, C3-10cycloalkyl, and 3-12 membered heterocyclyl;
each R6 and R7 is independently selected from hydrogen, halo, hydroxyl, C1-6alkyl, C1-6alkoxyl, C1-6haloalkyl, and C1-6haloalkoxyl;
R8 is selected from hydrogen, halo, hydroxyl, oxo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, —O—C2-6alkenyl, —O—C2-6alkynyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C6-10aryl, —O—5-10 membered heteroaryl, —O—C1-4alkylene-C3-10cycloalkyl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—C1-4alkylene-C6-10aryl, and —O—C1-4alkylene-5-10 membered heteroaryl;
R9 is absent or selected from hydrogen, halo, hydroxyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, —O—C2-6alkenyl, —O—C2-6alkynyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C6-10aryl, —O—5-10 membered heteroaryl, —O—C1-4alkylene-C3-10cycloalkyl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—C1-4alkylene-C6-10aryl, and —O—C1-4alkylene-5-10 membered heteroaryl;
wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, —O—C2-6alkenyl, —O—C2-6alkynyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C6-10aryl, —O—5-10 membered heteroaryl, —O—C1-4alkylene-C3-10cycloalkyl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—C1-4alkylene-C6-10aryl, and —O—C1-4alkylene-5-10 membered heteroaryl of R8 and R9 is independently optionally substituted with 1-5 RA;
R10 is selected from hydrogen, halo, hydroxyl, —CN, C1-6alkyl, C1-6alkoxyl, C1-6haloalkyl, and C1-6haloalkoxyl;
each R11, R12, R13, and R14 is independently selected from hydrogen, halo, hydroxyl, —CN, C1-6alkyl, C1-6alkoxy, and C1-6haloalkyl; or
R11 and R13 together with the atoms to which they are attached form a C3-6 cycloalkyl or 3-6 membered heterocyclyl; wherein the 3-6 membered heterocyclyl has one to three heteroatoms; and wherein each C3-6 cycloalkyl and 3-6 membered heterocyclyl is optionally substituted with one to three groups independently selected from halo, hydroxyl, —CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, and C1-6haloalkoxyl;
each RA is independently selected from halo, hydroxyl, oxo, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, C1-6haloalkyl, C1-6haloalkoxyl, —C1-4alkylene-O—C1-4alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, and —NRaaRbb;
wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, C1-6haloalkyl, C1-6haloalkoxyl, —C1-4alkylene-O—C1-4alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl of RA is independently substituted with one to three groups independently selected from halo, hydroxyl, —CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, and —NRaaRbb;
each Raa and Rbb is independently selected from hydrogen, C1-6alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —C1-6alkylene-C3-10cycloalkyl, —C1-6alkylene-3-12 membered heterocyclyl, —C1-6alkylene-C6-10aryl, and —C1-6alkylene-5-10 membered heteroaryl;
wherein each C1-6alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —C1-6alkylene-C3-10cycloalkyl, —C1-6alkylene-3-12 membered heterocyclyl, —C1-6alkylene-C6-10aryl, and —C1-6alkylene-5-10 membered heteroaryl of Raa and Rbb is independently optionally substituted with one to four groups independently selected from halo, C1-6alkyl, —CN, C1-6alkoxyl, and C1-6haloalkyl;
wherein the 3-12 membered heterocyclyl is a single ring or multiple rings having one to four heteroatoms independently selected from nitrogen, sulfur, phosphorus, —N(O)—, —S(O)—, and —S(O)2—; and wherein the multiple rings may be fused, bridged, or spiro; and
wherein the 5-10 membered heteroaryl is an aromatic group having a single ring or multiple rings; wherein the 5-10 membered heteroaryl contains one to four heteroatoms independently selected from nitrogen, oxygen, sulfur, —N(O)—, —S(O)—, and —S(O)2.