US 12,201,836 B2
Techniques for neuromodulation
Christopher Michael Puleo, Niskayuna, NY (US); Jeffrey Michael Ashe, Gloversville, NY (US); Victoria Eugenia Cotero, Watervliet, NY (US); and Michael Ernest Marino, Niskayuna, NY (US)
Assigned to GENERAL ELECTRIC COMPANY, Schenectady, NY (US)
Filed by General Electric Company, Schenectady, NY (US)
Filed on Jun. 8, 2021, as Appl. No. 17/342,186.
Application 17/342,186 is a continuation of application No. 16/091,486, granted, now 11,040,199, previously published as PCT/US2017/025971, filed on Apr. 4, 2017.
Claims priority of provisional application 62/325,828, filed on Apr. 21, 2016.
Claims priority of provisional application 62/318,035, filed on Apr. 4, 2016.
Prior Publication US 2021/0299449 A1, Sep. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61N 2/00 (2006.01)
CPC A61N 1/36071 (2013.01) [A61N 1/3606 (2013.01); A61N 1/36121 (2013.01); A61N 1/36153 (2013.01); A61N 1/36171 (2013.01); A61N 2/006 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method of neuromodulation, comprising:
applying one or more energy pulses to a neuron of a subject to deliver sufficient energy to the neuron to neurally modulate a lymphatic tissue in response to applying the one or more energy pulses;
acquiring image data of the lymphatic tissue using an ultrasound imaging probe; and
changing modulation parameters of the one or more energy pulses based on the image data.
 
12. A system for neuromodulation of lymphatic tissue, comprising:
an energy application device configured to apply one or more energy pulses to a neuron of a subject to deliver sufficient energy to the neuron to neurally modulate a lymphatic tissue in response to applying the one or more energy pulses;
a noninvasive ultrasound imaging probe configured to acquire image data of the lymphatic tissue before and after neurally modulating the lymphatic tissue; and
a controller configured to:
cause the energy application device to generate the one or more energy pulses according to modulation parameters;
identify a change in size of the lymphatic tissue caused by applying the one or more energy pulses based on the image data; and
change the modulation parameters based on the identified change in size of the lymphatic tissue.