US 12,201,757 B2
Photoactivated blood products and methods and apparatus for fabrication and use of same
Nicholas William Medendorp, Jr., Durham, NC (US); and Katelyn Reighard Crizer, Durham, NC (US)
Assigned to KNOW Bio, LLC, Morrisville, NC (US)
Appl. No. 17/611,782
Filed by KNOW Bio, LLC, Durham, NC (US)
PCT Filed May 22, 2020, PCT No. PCT/US2020/034287
§ 371(c)(1), (2) Date Nov. 16, 2021,
PCT Pub. No. WO2020/242971, PCT Pub. Date Dec. 3, 2020.
Claims priority of provisional application 62/852,732, filed on May 24, 2019.
Prior Publication US 2022/0233752 A1, Jul. 28, 2022
Int. Cl. A61N 5/06 (2006.01); A61K 35/16 (2015.01); A61K 38/18 (2006.01); A61M 1/02 (2006.01)
CPC A61M 1/0259 (2013.01) [A61K 35/16 (2013.01); A61K 38/1858 (2013.01); A61M 2202/0415 (2013.01); A61M 2202/0445 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method of making a light-irradiated plasma product from blood, the method comprising:
(a) processing a quantity of whole blood by controlling a spectral content of light applied to the quantity of whole blood such that a concentration of a growth factor in the quantity of whole blood is increased, wherein controlling the spectral content of the applied light comprises providing light in a wavelength range of from 660 nm to 1500 nm; and
(b) extracting a plasma product including the growth factor from the processed quantity of whole blood.