US 12,201,726 B2
Preserving functionally-coated API particles produced by solventless mixing processes in aqueous suspension
Rosaleen Mclaughlin, Swindon (GB); Adam Parker, Swindon (GB); and Jonathon Whitehouse, Swindon (GB)
Assigned to Catalent U.K. Swindon Zydis Limited, Swindon (GB)
Filed by Catalent U.K. Swindon Zydis Limited, Swindon (GB)
Filed on Nov. 18, 2021, as Appl. No. 17/529,827.
Application 17/529,827 is a continuation of application No. 16/797,934, filed on Feb. 21, 2020, granted, now 11,185,508.
Claims priority of provisional application 62/809,287, filed on Feb. 22, 2019.
Prior Publication US 2022/0071907 A1, Mar. 10, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/50 (2006.01); A61K 9/16 (2006.01); A61K 9/28 (2006.01); A61K 47/02 (2006.01); A61K 47/44 (2017.01)
CPC A61K 9/1635 (2013.01) [A61K 9/1623 (2013.01); A61K 9/1652 (2013.01); A61K 9/1658 (2013.01); A61K 9/1682 (2013.01); A61K 9/2813 (2013.01); A61K 9/288 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A pharmaceutical composition comprising:
a coated API particle comprising;
a first coating comprising a wax; and
a second coating comprising silica partially embedded in and/or embedded in the wax,
wherein the coated API particle comprises 0.5-2.5% w/w silica and the silica produces a slower dissolution profile for the API as compared to API without silica.