US 12,201,717 B2
Compositions and methods for supporting skin barrier homeostasis
Amy Gordinier, Halifax (CA); Marc Cornell, Freehold, NJ (US); and Erica Arnoldin, Waverley (CA)
Assigned to Skinfix Inc., Halifax (CA)
Filed by Skinfix Inc., Halifax (CA)
Filed on Oct. 30, 2023, as Appl. No. 18/497,102.
Claims priority of provisional application 63/381,643, filed on Oct. 31, 2022.
Prior Publication US 2024/0139095 A1, May 2, 2024
Int. Cl. A61K 8/9789 (2017.01); A61K 8/31 (2006.01); A61K 8/34 (2006.01); A61K 8/365 (2006.01); A61K 8/42 (2006.01); A61K 8/63 (2006.01); A61K 8/64 (2006.01); A61K 8/67 (2006.01); A61K 8/9717 (2017.01); A61Q 19/00 (2006.01); A61Q 19/08 (2006.01)
CPC A61K 8/9789 (2017.08) [A61K 8/31 (2013.01); A61K 8/345 (2013.01); A61K 8/365 (2013.01); A61K 8/42 (2013.01); A61K 8/63 (2013.01); A61K 8/64 (2013.01); A61K 8/673 (2013.01); A61K 8/9717 (2017.08); A61Q 19/007 (2013.01); A61Q 19/08 (2013.01); A61K 2800/5922 (2013.01); A61K 2800/884 (2013.01)] 12 Claims
 
1. A composition intended for application onto human skin experiencing oxidative stress, the composition comprising:
(1) a first active blend in an amount from about 0.25% to about 6% by weight of at least:
(a) Jojoba oil/Macadamia seed oil esters;
(b) squalene;
(c) phytosteryl macadamiate; and
(d) phytosterols;
(2) a second active blend in an amount of from about 0.1% to about 6% by weight of at least:
(e) epidermal growth factor (EGF);
(f) insulin-like growth factor-1 (IGF-1);
(g) acidic fibroblast growth factor (aFGF);
(h) basic fibroblast growth factor (bFGF);
(i) vascular endothelial growth factor (VEGF);
(j) vitamin B9; and
(k) acetyl glutamine; and
(3) a third active blend in an amount of about 0.25% to about 6% by weight of at least:
(l) an extract of lithothamnium calcareum;
(m) pentylene glycol;
(n) lactic acid; and
(o) glycerin;
(4) an emulsifier; and
(5) a dermatologically acceptable carrier,
wherein (1)-(3) are employed in amounts sufficient to help support skin barrier health, integrity, and functionality, wherein all weights are based on the total weight of the composition.