	US 12,201,648 B2
	Methods of treating chronic wounds using electrospun fibers
Jason Chakroff, Columbus, OH (US); Ronald Lloyd Bracken, Monroe, GA (US); and Jed Johnson, London, OH (US)
Assigned to NFS IP Holdings, LLC, Dublin, OH (US)
Filed by NFS IP Holdings, LLC, Dublin, OH (US)
Filed on Jan. 10, 2023, as Appl. No. 18/152,240.
Application 18/152,240 is a continuation of application No. 16/710,603, filed on Dec. 11, 2019, granted, now 11,576,927.
Claims priority of provisional application 62/778,024, filed on Dec. 11, 2018.
Prior Publication US 2023/0285445 A1, Sep. 14, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/765 (2006.01); A61P 17/02 (2006.01)

CPC A61K 31/765 (2013.01) [A61P 17/02 (2018.01)]

11 Claims

1. A method of reducing an initial pH of a wound, the method comprising:

applying a scaffold to the wound, the scaffold comprising fiber fragments, the fiber fragments comprising at least a first electrospun polymer and a second electrospun polymer, wherein the first electrospun polymer and the second electrospun polymer comprise a polymer selected from the group consisting of polyglycolic acid, poly(lactide-co-caprolactone), polydioxanone, and poly(lactide-co-glycolide); and

allowing at least a portion of the scaffold to degrade over a time period of about 3 days to about 21 days, thereby producing an acidic byproduct having a pH lower than the initial pH of the wound, wherein the acidic byproduct reduces the initial pH of the wound to a target pH from about 4.0 to about 6.0.