US 12,201,643 B2
Mechanochemical dynamic for focal cancer treatment
King C. Li, Urbana, IL (US); Gun Kim, Urbana, IL (US); Qiong Wu, Urbana, IL (US); Jeffrey S. Moore, Savoy, IL (US); and Yun-Sheng Chen, Champaign, IL (US)
Assigned to The Board of Trustees of the University of Illinois, Urbana, IL (US)
Filed by THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US)
Filed on Oct. 14, 2022, as Appl. No. 17/965,908.
Claims priority of provisional application 63/256,239, filed on Oct. 15, 2021.
Prior Publication US 2023/0119684 A1, Apr. 20, 2023
Int. Cl. A61K 31/655 (2006.01); A61K 9/06 (2006.01); A61K 31/10 (2006.01); A61K 31/327 (2006.01); A61K 47/10 (2017.01); A61K 47/34 (2017.01); A61P 35/00 (2006.01)
CPC A61K 31/655 (2013.01) [A61K 9/06 (2013.01); A61K 31/10 (2013.01); A61K 31/327 (2013.01); A61K 47/10 (2013.01); A61K 47/34 (2013.01); A61P 35/00 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A method of generating reactive oxygen species comprising contacting a composition comprising one or more azo-mechanophores covalently linked to a hydrogel matrix or biodegradable elastomer matrix wherein the one or more azo-mechanophores are present in the hydrogel matrix or biodegradable elastomer matrix at about 3.0 wt % to about 15 wt % with high intensity focused ultrasound (HIFU).