US 12,201,615 B2
Methods and compositions for treatment of mydriasis
Mina Sooch, Bloomfield, MI (US); Alan R. Meyer, North Riverside, IL (US); Konstantinos Charizanis, Ypsilanti, MI (US); Bernhard Hoffmann, Lake Forest, IL (US); and William H. Pitlick, Seattle, WA (US)
Assigned to Opus Genetics, Inc., Farmington Hills, MI (US)
Filed by Opus Genetics, Inc., Farmington Hills, MI (US)
Filed on Jul. 29, 2022, as Appl. No. 17/877,558.
Application 17/877,558 is a continuation of application No. 16/841,006, filed on Apr. 6, 2020, granted, now 11,400,077.
Application 16/841,006 is a continuation of application No. PCT/US2019/058182, filed on Oct. 25, 2019.
Claims priority of provisional application 62/751,391, filed on Oct. 26, 2018.
Prior Publication US 2023/0040217 A1, Feb. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/417 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/4178 (2006.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61P 27/08 (2006.01); A61P 27/10 (2006.01)
CPC A61K 31/417 (2013.01) [A61K 31/4178 (2013.01); A61P 27/08 (2018.01); A61P 27/10 (2018.01); A61K 9/0048 (2013.01); A61K 9/08 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01)] 32 Claims
 
1. A method of treating mydriasis in a human patient due to said patient having received one or more of tropicamide, phenylephrine, or a pharmaceutically acceptable salt thereof, comprising administering to an eye of the human patient in need thereof a dosage of phentolamine mesylate to thereby treat the mydriasis, wherein the dosage is topically administered to the patient's eye as one eye drop of a 1% (w/w) phentolamine mesylate solution, and at two hours after the dosage of phentolamine mesylate is administered to the patient's eye there is at least a 30% reduction in pupil diameter in said eye of the patient measured under photopic conditions.