| CPC A61K 31/404 (2013.01) [A61K 31/401 (2013.01); G01N 27/026 (2013.01); G01N 27/3272 (2013.01)] | 20 Claims |
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1. A method for screening a modulator of a viral infection, comprising:
providing a biosensing platform including:
an insulating support;
a working electrode formed from an electrically conductive layer deposited on a surface of the insulating support; and
angiotensin converting enzyme 2 (ACE2) or a fragment thereof coated on the working electrode;
pretreating the working electrode of the biosensing platform with a modulator candidate;
contacting the working electrode with a spike protein or a fragment thereof from a virus of interest in absence or presence of the modulator candidate; and
measuring a level of electrochemical impedance of the working electrode,
wherein a difference in the level of the electrochemical impedance of the working electrode pretreated with the modulator candidate compared to a reference level indicates the modulator candidate as the modulator capable of altering an interaction of the ACE2 and the spike protein or a variant thereof, thereby modulating the viral infection.
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