US 12,201,594 B2
Methods and compositions for treatment of pain using capsaicin
James N. Campbell, Baltimore, MD (US); Peter D. Hanson, Prides Crossing, MA (US); and Randall Stevens, Rockport, MA (US)
Assigned to Centrexion Therapeutics Corporation, Boston, MA (US)
Filed by Centrexion Therapeutics Corporation, Boston, MA (US)
Filed on Jun. 4, 2021, as Appl. No. 17/339,414.
Application 17/339,414 is a continuation of application No. 16/984,384, filed on Aug. 4, 2020, granted, now 11,026,903.
Application 16/984,384 is a continuation of application No. 16/631,277, abandoned, previously published as PCT/US2018/043094, filed on Jul. 20, 2018.
Claims priority of provisional application 62/535,003, filed on Jul. 20, 2017.
Prior Publication US 2021/0299072 A1, Sep. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/167 (2006.01); A61F 7/00 (2006.01); A61F 7/10 (2006.01); A61K 9/00 (2006.01); A61P 19/02 (2006.01)
CPC A61K 31/167 (2013.01) [A61F 7/10 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61P 19/02 (2018.01); A61F 2007/0042 (2013.01)] 29 Claims
 
1. A method of ameliorating joint pain in a human patient, comprising:
a. optionally applying a cooling article to a human patient's skin in proximity to a joint in need of pain relief therapy; then
b. optionally administering a local anesthetic agent into said joint; then
c. applying a cooling article to the patient's skin in proximity to said joint to achieve a temperature in the range of from 28° C. to 30° C. for tissue or fluid in the interior of the joint; then
d. administering by injection into said joint a pharmaceutical composition comprising capsaicin in order to deliver a dose of capsaicin in an amount of 1 mg; and then the joint is flexed 5 times; and then
e. optionally applying a cooling article to the patient's skin in proximity to said joint; to thereby ameliorate joint pain in the human patient,
wherein the joint pain is osteoarthritic joint pain, the joint is a knee joint, and
the following additional step is performed between steps (c) and (d): administering into said joint a pharmaceutical composition comprising a single pain-relief local anesthetic agent selected from the group consisting of lidocaine and a pharmaceutically acceptable salt thereof, in order to deliver a dose of lidocaine in an amount ranging from about 0.1 g to about 0.5 g;
wherein the patient does not receive any pain-relief medicine other than (i) the local anesthetic agent recited in step (b) and in said additional step between steps (c) and (d) and (ii) capsaicin.