US 12,201,422 B2
Methods of manufacture to optimize performance of transdermal sampling and analysis device
Joseph J. Vidalis, Bethesda, MD (US); Joseph A. Marcanio, Greensburg, PA (US); John Frederick Currie, Bethesda, MD (US); Helena Woodvine Snyder, Washington, DC (US); and Vikas Bhatia, Gaithersburg, MD (US)
Assigned to Cambridge Medical Technologies LLC, Rockville, MD (US)
Filed by Cambridge Medical Technologies LLC, Carson City, NV (US)
Filed on Dec. 21, 2020, as Appl. No. 17/128,287.
Application 17/128,287 is a division of application No. 14/208,344, filed on Mar. 13, 2014, granted, now 10,898,116.
Claims priority of provisional application 61/791,970, filed on Mar. 15, 2013.
Prior Publication US 2021/0128036 A1, May 6, 2021
Int. Cl. A61B 5/15 (2006.01); A61B 5/145 (2006.01); A61B 5/1486 (2006.01); A61B 5/151 (2006.01); A61B 5/157 (2006.01)
CPC A61B 5/150076 (2013.01) [A61B 5/14532 (2013.01); A61B 5/1486 (2013.01); A61B 5/150022 (2013.01); A61B 5/150274 (2013.01); A61B 5/150862 (2013.01); A61B 5/15134 (2013.01); A61B 5/157 (2013.01)] 7 Claims
OG exemplary drawing
 
5. A method of making a transdermal sampling and analysis device, comprising:
forming a base structure with at least a first electrode;
forming a lid structure configured to be positioned above the at least first electrode, wherein the lid structure has a plurality of channel support structures; and
attaching the lid structure to the base structure using an adhesive material on surfaces of the plurality of channel support structures,
wherein attaching the lid structure to the base structure forms a plurality of channels in a reservoir between the plurality of channel support structures,
wherein the reservoir comprises:
a circular collection portion configured to collect a biological sample obtained through permeable skin barrier cells, wherein the circular collection portion is substantially parallel to a plane of the skin; and
a sensing chamber portion configured to receive the biological sample from the circular collection portion, wherein the sensing chamber portion surrounds a periphery of the circular collection portion substantially parallel to the plane of the skin, wherein the at least first electrode is located proximate to the sensing chamber portion.