US 12,201,344 B2
Systems and methods for pulsed-field ablation with charge-balanced waveforms
Dorin Panescu, San Jose, CA (US); Tho Nguyen, Huntington Beach, CA (US); Henning Ebert, Berlin (DE); Steffen Holzinger, Berlin (DE); and Sven Bode, Berlin (DE)
Assigned to CRC EP, INC., Lake Oswego, OR (US)
Filed by CRC EP, INC., Lake Oswego, OR (US)
Filed on Mar. 13, 2024, as Appl. No. 18/604,179.
Application 18/604,179 is a continuation of application No. PCT/US2023/012201, filed on Feb. 2, 2023.
Claims priority of provisional application 63/306,162, filed on Feb. 3, 2022.
Prior Publication US 2024/0216039 A1, Jul. 4, 2024
Int. Cl. A61B 18/12 (2006.01); A61B 18/14 (2006.01); A61B 34/00 (2016.01); A61B 18/00 (2006.01)
CPC A61B 18/1206 (2013.01) [A61B 18/1492 (2013.01); A61B 34/25 (2016.02); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00767 (2013.01); A61B 2018/00827 (2013.01); A61B 2018/00875 (2013.01); A61B 2018/00892 (2013.01); A61B 2018/126 (2013.01); A61B 2018/1286 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A generator of a substantially charge-balanced pulse for application to at least one electrode pair of a medical device, the generator comprising:
a pulse-shaping output stage (POS) for coupling to the at least one electrode pair;
an internal pulse generator for applying a plurality of internal pulses to the pulse-shaping output stage, the plurality of internal pulses forming a pulse train;
wherein the pulse-shaping output stage comprises a transformer and at least one capacitor, such that each internal pulse of the pulse train is transformed into a substantially charge-balanced pulse having an interphase period of zero seconds; and
the pulse-shaping output stage is configured to deliver each charge-balanced pulse of the pulse train to the at least one electrode pair.