US 11,875,982 B2
Multi-modal ionization for mass spectrometry
Nam Duc Lai, San Jose, CA (US); Krisztian Gabor Torma, San Jose, CA (US); Ming Chai, Union City, CA (US); William Allen Escobar, San Jose, CA (US); Xiaoguang Wu, San Jose, CA (US); Masayuki Kamata, Sunnyvale, CA (US); and Wei Yang Terziyan, Los Altos Hills, CA (US)
Assigned to BaySpec, Inc., San Jose, CA (US)
Filed by BaySpec, Inc., San Jose, CA (US)
Filed on Feb. 17, 2023, as Appl. No. 18/111,260.
Application 18/111,260 is a continuation of application No. 17/389,123, filed on Jul. 29, 2021, granted, now 11,621,155.
Prior Publication US 2023/0207301 A1, Jun. 29, 2023
Int. Cl. H01J 49/00 (2006.01); H01J 49/10 (2006.01)
CPC H01J 49/107 (2013.01) [H01J 49/0031 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for multi-modal ionization comprising:
receiving an analyte;
ionizing some molecules of the analyte using a first ionization method and a first ionization source to produce first ions;
ionizing other molecules of the analyte using a second ionization method and a second ionization source to produce second ions; and
providing the first and second ions to a mass analyzer, wherein the second ionization source comprises a counter electrode and a high-voltage electrode separated by a dielectric barrier, and wherein an end of the dielectric barrier and an inlet of the mass analyzer are electrically coupled to a ground.