CPC G01N 33/6896 (2013.01) [A61K 31/69 (2013.01); A61K 31/7105 (2013.01); A61K 45/06 (2013.01); A61P 25/02 (2018.01); G01N 33/574 (2013.01); G01N 2800/2842 (2013.01); G01N 2800/52 (2013.01)] | 3 Claims |
1. A method for the treatment of chemotherapy-induced peripheral neuropathy in a subject having a cancer, comprising:
a) obtaining a first sample from the subject before treatment with an anti-cancer agent;
b) obtaining a second sample from the subject after treatment with the anti-cancer agent;
c) determining the expression level of a delta-2-tubulin in the second sample is increased compared to the expression level in the first sample; and
d) administering an siRNA or shRNA targeting cytosolic carboxypeptidase 1 (CCP1), wherein the first sample and the second sample comprise a sample of nervous tissue.
|