US 11,874,212 B2
Blood analysis method, blood analysis system and storage medium
Bo Ye, Shenzhen (CN); Wenbo Zheng, Shenzhen (CN); Huan Qi, Shenzhen (CN); and Zhaoyang Li, Shenzhen (CN)
Assigned to Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen (CN)
Filed by Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen (CN)
Filed on Oct. 23, 2020, as Appl. No. 17/078,740.
Application 17/078,740 is a continuation of application No. PCT/CN2019/084684, filed on Apr. 26, 2019.
Claims priority of application No. PCT/CN2018/085195 (WO), filed on Apr. 28, 2018.
Prior Publication US 2021/0041343 A1, Feb. 11, 2021
Int. Cl. G01N 15/14 (2006.01); G01N 15/10 (2006.01); G01N 33/49 (2006.01)
CPC G01N 15/1429 (2013.01) [G01N 15/1031 (2013.01); G01N 33/49 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A blood analysis method, comprising the following steps:
providing a blood sample;
mixing a first aliquot of the blood sample with a diluent agent to prepare a first test sample;
mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample, wherein red blood cells in the second test sample are lysed by the lytic reagent;
detecting electrical impedance signals of the first test sample;
detecting at least two types of optical signals of the second test sample;
acquiring first volume distribution data of the first test sample based on the electrical impedance signals;
generating a scattergram of the second test sample based on the at least two types of optical signals; identifying a non-white blood cell region in the scattergram based on the at least two types of optical signals; and acquiring second volume distribution data of the second test sample based on the non-white blood cell region;
acquiring red blood cell detection data of the blood sample;
determining whether the blood sample may contain schistocytes based on the first volume distribution data, the second volume distribution data and the red blood cell detection data; and
providing an alarm for indicating that the blood sample may be a sample containing schistocytes if the blood sample is determined to contain schistocytes.