US 11,874,209 B2
Isolation device and isolation method for isolating target particles from liquid samples
Yuchao Chen, Rodeo, CA (US)
Assigned to Shenzhen Huixin Life Technologies Co., Ltd, Shenzhen (CN)
Filed by Shenzhen Huixin Life Technologies Co., Ltd, Shenzhen (CN)
Filed on Jan. 14, 2022, as Appl. No. 17/576,654.
Application 17/576,654 is a continuation in part of application No. PCT/CN2019/096425, filed on Jul. 17, 2019.
Prior Publication US 2022/0136938 A1, May 5, 2022
Int. Cl. G01N 33/68 (2006.01); G01N 21/33 (2006.01); G01N 21/64 (2006.01); G01N 33/52 (2006.01); C07C 309/65 (2006.01); C07C 309/73 (2006.01); A01N 1/02 (2006.01); G01N 1/40 (2006.01); G01N 33/543 (2006.01); G01N 33/532 (2006.01); G01N 33/569 (2006.01); G01N 35/00 (2006.01); G01M 3/02 (2006.01); G01N 35/10 (2006.01); G01N 1/34 (2006.01)
CPC G01N 1/34 (2013.01) [G01N 1/4005 (2013.01); G01N 2001/4016 (2013.01)] 6 Claims
OG exemplary drawing
 
1. An isolation device for isolation of target particles from a plurality of liquid samples, the isolation device comprising:
a plurality of isolation chips each comprising:
a sample reservoir configured for receiving one of the plurality of liquid samples;
a first outlet and a second outlet disposed at opposite sides of the sample reservoir;
a vacuum system comprising:
a first vacuum pump connected to the first outlet of each of the plurality of isolation chips, the first vacuum pump configured to generate a negative pressure in each of the plurality of isolation chips through a corresponding first outlet; and
a second vacuum pump connected to the second outlet of each of the plurality of isolation chips, the second vacuum pump configured to generate a negative pressure in each of the plurality of isolation chips through a corresponding second outlet, to isolate the target particles from each of the plurality of liquid samples in a corresponding sample reservoir;
a first support platform adapted to rotate about a first shaft and configured to support the plurality of isolation chips, the plurality of isolation chips arranged around the first shaft and moved to a first preset position when the first support platform rotates;
a second support platform adapted to rotate about a second shaft and configured to support the plurality of liquid samples, the plurality of liquid samples arranged around the second shaft and moved to a second preset position when the second support platform rotates; and
a liquid collector comprising at least one sampling member, the at least one sampling member adapted to rotate about a third shaft to form a sampling trajectory, the first preset position and the second preset position disposed on the sampling trajectory, the at least one sampling member configured to collect one of the plurality of liquid samples at the second preset position and add the collected liquid sample to one of the plurality of isolation chips at the first preset position.