US 11,873,272 B2
Antimicrobial and antiviral sulfur containing glycerol monoester derivatives
Dayton T. Reardan, Shorewood, MN (US); Paul Brennan, Oxfordshire (GB); and Patrick Schlievert, Iowa City, IA (US)
Assigned to Niche Biopharmaceuticals LLC, Shorewood, MN (US)
Filed by Niche Biopharmaceuticals LLC, Shorewood, MN (US)
Filed on Jan. 31, 2023, as Appl. No. 18/162,301.
Application 18/162,301 is a continuation of application No. 17/647,232, filed on Jan. 6, 2022, granted, now 11,365,176, issued on Jun. 21, 2022.
Application 17/647,232 is a continuation of application No. 16/948,453, filed on Sep. 18, 2020, granted, now 11,572,342.
Prior Publication US 2023/0174473 A1, Jun. 8, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 327/36 (2006.01); A61P 31/04 (2006.01); C07D 317/24 (2006.01)
CPC C07C 327/36 (2013.01) [A61P 31/04 (2018.01); C07D 317/24 (2013.01)] 20 Claims
 
1. A compound of Formula (I),

OG Complex Work Unit Chemistry
wherein:
R1 is selected from the group consisting of alkyl, alkenyl, and alkynyl;
R2 and R3 are independently selected from the group consisting of hydrogen, COR4, —CON(H)R4, —CO2R4, or P(O)(OR4)2; or, taken together with the carbon to which they are attached, R2 and R3 may form a 3- to 5-membered aliphatic carbocyclic ring;
R4 is H, alkyl, alkenyl, aryl, cycloalkyl, heterocyclyl, or heteroaryl; and
X is S;
or a pharmaceutically acceptable salt thereof.