US 11,873,265 B2
Method for preparing benzyl amine compound
Hongmei Sun, Suzhou (CN); and Dan Wang, Suzhou (CN)
Assigned to SOOCHOW UNIVERSITY, Suzhou (CN)
Filed by SOOCHOW UNIVERSITY, Suzhou (CN)
Filed on Apr. 23, 2021, as Appl. No. 17/239,500.
Application 17/239,500 is a continuation of application No. PCT/CN2018/112511, filed on Oct. 29, 2018.
Prior Publication US 2021/0238121 A1, Aug. 5, 2021
Int. Cl. C07D 231/56 (2006.01); C07C 209/02 (2006.01); B01J 31/22 (2006.01); C07C 211/48 (2006.01)
CPC C07C 209/02 (2013.01) [B01J 31/22 (2013.01); C07C 211/48 (2013.01)] 5 Claims
 
1. A method for preparing a benzylamine compound comprising:
adding an aryl compound, an arylamine, an oxidizing agent, and a catalyst to form a reaction mixture; and
conducting a reaction by heating the reaction mixture to obtain the benzylamine compound,
wherein:
the benzylamine compound has the following structure:

OG Complex Work Unit Chemistry
the aryl compound has the following structure:

OG Complex Work Unit Chemistry
the arylamine has the following structure:

OG Complex Work Unit Chemistry
the oxidizing agent is di-tert-butyl peroxide;
the catalyst is an ionic iron (III) complex having the following structure:

OG Complex Work Unit Chemistry
and
R is hydrogen or methyl; R1 is cyano, nitro, trifluoromethyl or acetyl; and R2 is hydrogen or methyl; and Ar is phenyl, p-tert-butylphenyl, o-methylphenyl, mesitylphenyl, p-chlorophenyl, o-chlorophenyl, naphthyl, or thienyl.