US 11,872,328 B2
Devices, kits and methods for reducing and/or preventing intra-abdominal adhesions
Yoav Mintz, Jerusalem (IL); Nikolai Kunicher, Pardesia (IL); and Tali Tavor Re'em, Modiin (IL)
Assigned to HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD., Jerusalem (IL); and AZRIELI COLLEGE OF ENGINEERING JERUSALEM, Jerusalem (IL)
Appl. No. 16/643,061
Filed by HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD., Jerusaelm (IL); and AZRIELI COLLEGE OF ENGINEERING JERUSALEM, Jerusalem (IL)
PCT Filed Aug. 28, 2018, PCT No. PCT/IL2018/050949
§ 371(c)(1), (2) Date Feb. 28, 2020,
PCT Pub. No. WO2019/043699, PCT Pub. Date Mar. 7, 2019.
Claims priority of provisional application 62/551,831, filed on Aug. 30, 2017.
Prior Publication US 2020/0330210 A1, Oct. 22, 2020
Int. Cl. A61F 2/00 (2006.01); A61L 31/04 (2006.01); A61K 31/734 (2006.01); A61K 33/14 (2006.01)
CPC A61L 31/042 (2013.01) [A61F 2/0063 (2013.01); A61K 31/734 (2013.01); A61K 33/14 (2013.01); A61F 2002/0072 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A method for reducing or treating post-operative adhesions in a target site within a body of a subject, the method comprising:
introducing an applicator into a target site within a body of a subject, wherein the applicator is configured for applying an anti-adhesive composition to an implanted medical device fixed and deployed in the target site; and
applying in situ the anti-adhesive composition onto the implanted medical device, wherein said method is performed during or following an interventional medical procedure, and
wherein said applying in situ the anti-adhesive composition onto the implanted medical device comprises the following steps:
a. spreading, onto the implanted medical device, a first composition comprising an anti-adhesive substance, wherein the anti-adhesive substance is a viscous liquid comprising alginate that has been partially crosslinked using calcium gluconate, such that the alginate has a Ca2+ concentration of about 0.25-3% w/v; and
b. applying, onto the first composition, a second composition comprising a bivalent cation crosslinker, thereby transforming the viscous liquid into a gel.