CPC A61L 31/042 (2013.01) [A61F 2/0063 (2013.01); A61K 31/734 (2013.01); A61K 33/14 (2013.01); A61F 2002/0072 (2013.01)] | 12 Claims |
1. A method for reducing or treating post-operative adhesions in a target site within a body of a subject, the method comprising:
introducing an applicator into a target site within a body of a subject, wherein the applicator is configured for applying an anti-adhesive composition to an implanted medical device fixed and deployed in the target site; and
applying in situ the anti-adhesive composition onto the implanted medical device, wherein said method is performed during or following an interventional medical procedure, and
wherein said applying in situ the anti-adhesive composition onto the implanted medical device comprises the following steps:
a. spreading, onto the implanted medical device, a first composition comprising an anti-adhesive substance, wherein the anti-adhesive substance is a viscous liquid comprising alginate that has been partially crosslinked using calcium gluconate, such that the alginate has a Ca2+ concentration of about 0.25-3% w/v; and
b. applying, onto the first composition, a second composition comprising a bivalent cation crosslinker, thereby transforming the viscous liquid into a gel.
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