US 11,872,327 B2
Medical device
Tomohiro Kato, Otsu (JP); and Masataka Nakamura, Otsu (JP)
Assigned to Toray Industries, Inc., Tokyo (JP)
Appl. No. 16/611,078
Filed by Toray Industries, Inc., Tokyo (JP)
PCT Filed Apr. 19, 2018, PCT No. PCT/JP2018/016155
§ 371(c)(1), (2) Date Nov. 5, 2019,
PCT Pub. No. WO2018/207586, PCT Pub. Date Nov. 15, 2018.
Claims priority of application No. 2017-093709 (JP), filed on May 10, 2017.
Prior Publication US 2020/0164112 A1, May 28, 2020
Int. Cl. A61L 29/14 (2006.01); A61L 15/26 (2006.01); A61L 15/60 (2006.01); A61L 27/18 (2006.01); A61L 27/52 (2006.01); A61L 29/06 (2006.01); A61L 31/06 (2006.01); A61L 31/14 (2006.01); C08G 77/442 (2006.01); G02B 1/04 (2006.01)
CPC A61L 29/145 (2013.01) [A61L 15/26 (2013.01); A61L 15/60 (2013.01); A61L 27/18 (2013.01); A61L 27/52 (2013.01); A61L 29/06 (2013.01); A61L 31/06 (2013.01); A61L 31/145 (2013.01); C08G 77/442 (2013.01); G02B 1/043 (2013.01); C08G 2220/00 (2013.01)] 9 Claims
 
1. A medical device comprising a silicone hydrogel satisfying the following conditions:
(1) a water content in hydrous state which is within the range of 20% by mass to 70% by mass;
(2) a content of silicon atoms with respect to the total mass in dry state which is within the range of 8% by mass to 30% by mass; and
(3) a tensile elastic modulus in dry state which is within the range of 0.1 MPa to 3.5 MPa;
wherein the silicone hydrogel is a polymer comprising:
a repeat unit (A) in an amount within the range of 5% by mass to 50% by mass with respect to the total mass of the silicone hydrogel in dry state, the repeat unit (A) being derived from a monomer represented by General Formula (I):

OG Complex Work Unit Chemistry
wherein, in General Formula (I), Ra represents hydrogen or a methyl group; Rb represents an alkyl group having from 1 to 15 carbon atoms; and n represents an integer within the range of 1 to 40;
a repeat unit (B) in an amount within the range of 20% by mass to 70% by mass with respect to the total mass of the silicone hydrogel in dry state, the repeat unit (B) being derived from a monomer represented by General Formula (a):

OG Complex Work Unit Chemistry
wherein, in General Formula (a), R1 represents a hydrogen atom or a methyl group; R2 represents a propylene group; R3 to R6 each independently represent a C1-C4 alkyl group; R7 represents a C1-C6 alkyl group which is optionally substituted; and k represents an integer of 1 to 200 which optionally has a distribution; and
a repeat unit (C) in an amount within the range of 5% by mass to 50% by mass with respect to the total mass of the silicone hydrogel in dry state, the repeat unit (C) being derived from a monomer represented by General Formula (II-1):

OG Complex Work Unit Chemistry
or General Formula (II-2):

OG Complex Work Unit Chemistry
wherein, in General Formula (II-1) and General Formula (II-2), R8 and R11 each independently represent a hydrogen atom or a methyl group; R9 and R10, and R12 and R13 represent a hydrogen atom(s), and/or a C1-C20 alkyl group(s) which is/are either branched or linear, which optionally contain(s) a cyclic structure, and which is/are optionally substituted; and R12 and R13 optionally bind to each other to form a ring;
with the proviso that the total of the repeat units (A), (B), and (C) does not exceed 100% by mass with respect to the total mass of the silicone hydrogel in dry state; and
wherein the total of the repeat units (A), (B), and (C) exceeds 50% by mass with respect to the total mass of the silicone hydrogel in dry state.