	US 11,872,320 B2
	Method for treating osteoarthritis
Hiroyuki Sato, Tokyo (JP); and Hirochika Takano, Tokyo (JP)
Assigned to HISAMITSU PHARMACEUTICAL CO., INC., Tosu (JP)
Filed by HISAMITSU PHARMACEUTICAL CO., INC., Tosu (JP)
Filed on Feb. 25, 2021, as Appl. No. 17/184,797.
Prior Publication US 2022/0265567 A1, Aug. 25, 2022
Int. Cl. A61K 47/12 (2006.01); A61K 31/196 (2006.01); A61K 9/70 (2006.01); A61K 9/00 (2006.01)

CPC A61K 9/7053 (2013.01) [A61K 9/0014 (2013.01); A61K 9/7076 (2013.01); A61K 31/196 (2013.01); A61K 47/12 (2013.01)]

50 Claims

1. A method for treating osteoarthritis, the method comprising: a step of administering a patch to a patient,

wherein the patch comprises a backing layer and an adhesive layer laminated on the backing layer,

wherein the adhesive layer comprises an adhesive base, diclofenac sodium, dimethyl sulfoxide, and one or more organic acids,

wherein a content of the organic acid is 6 mass % to 8 mass % with respect to a total mass of the adhesive layer,

wherein the patch is applied to an affected part of the patient once a day,

wherein a dose of diclofenac sodium per administration is 70 mg to 150 mg, and

wherein the patch comprises a styrene-isoprene-styrene block copolymer and polyisobutylene as the adhesive base, and wherein the patch shows an amount of diclofenac released of 13 mg to 16 mg during a single dose and a release rate of diclofenac of 8.6% to 10.7%.