US 11,872,316 B2
Delivery system
Elger Funda, Kaiseraugst (CH); Odile Krainz, Kaiseraugst (CH); and Robert Steinert, Kaiseraugst (CH)
Assigned to DSM IP ASSETS B.V., Heerlen (NL)
Appl. No. 16/761,053
Filed by DSM IP ASSETS B.V., Heerlen (NL)
PCT Filed Oct. 30, 2018, PCT No. PCT/EP2018/079665
§ 371(c)(1), (2) Date May 1, 2020,
PCT Pub. No. WO2019/086427, PCT Pub. Date May 9, 2019.
Claims priority of application No. 17199806 (EP), filed on Nov. 3, 2017.
Prior Publication US 2021/0177766 A1, Jun. 17, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/28 (2006.01); A23K 20/174 (2016.01); A23K 40/30 (2016.01); A23P 20/10 (2016.01); A23L 33/15 (2016.01); A61K 31/525 (2006.01); A23P 10/30 (2016.01); A61K 8/11 (2006.01); A61K 8/67 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 9/50 (2006.01)
CPC A61K 9/286 (2013.01) [A23K 20/174 (2016.05); A23K 40/30 (2016.05); A23L 33/15 (2016.08); A23P 10/30 (2016.08); A23P 20/105 (2016.08); A61K 8/11 (2013.01); A61K 8/673 (2013.01); A61K 9/2095 (2013.01); A61K 9/2813 (2013.01); A61K 9/2886 (2013.01); A61K 9/4833 (2013.01); A61K 9/5026 (2013.01); A61K 9/5036 (2013.01); A61K 9/5073 (2013.01); A61K 9/5089 (2013.01); A61K 31/525 (2013.01); A23V 2002/00 (2013.01)] 10 Claims
 
1. A particulate delivery system comprising coated particles adapted to deliver at least one nutraceutical to large intestines of a patient, wherein each of the coated particles consists of:
(a) 10-85 wt. %, based on total weight of the delivery system, of a particulate solid core consisting of butyric acid and/or salts thereof as a nutraceutical,
(b) 1-20 wt. %, based on total weight of the delivery system, of an inner coating having a substantially uniform thickness of 5 μm to 20 μm which covers the solid core, wherein the inner coating comprises at least one fermentable crosslinked biopolymer, and
(c) 1-30 wt. %, based on total weight of the delivery system, of an outer coating having a substantially uniform thickness of 10 μm to 30 μm which covers the inner coating, wherein the outer coating is formed of a material resistant to stomach and small intestine conditions to thereby allow release of the at least one nutraceutical in the large intestines of the patient.