US 11,872,315 B2
Method for blood plasma protein activity preservation
Cheng-Yao Su, Taipei (TW); Chung Chin Sun, Taipei (TW); and Shan Shue Wang, Taipei (TW)
Assigned to SUN, CHUNG CHIN, Taipei (TW)
Appl. No. 16/472,111
Filed by Chung Chin Sun, Taipei (TW)
PCT Filed Dec. 21, 2016, PCT No. PCT/CN2016/111228
§ 371(c)(1), (2) Date Jun. 20, 2019,
PCT Pub. No. WO2018/112780, PCT Pub. Date Jun. 28, 2018.
Prior Publication US 2020/0085747 A1, Mar. 19, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/19 (2006.01); A61K 35/16 (2015.01)
CPC A61K 9/19 (2013.01) [A61K 35/16 (2013.01)] 1 Claim
 
1. A method for blood plasma fibrinogen activity preservation for up to six months, comprising: mixing blood plasma with a combination of protectants to obtain a mixture; and lyophilizing the mixture, wherein the combination of protectants is selected from the group consisting of:
(a) a combination consisting of 1% triglyceride, 1.6% glycerol, and 0.8% propylene glycol;
(b) a combination consisting of 0.4% triglyceride, 4% glycerol, and 0.8% dextran;
(c) a combination consisting of 0.1% triglyceride, 4% glycerol, and 2% sucrose;
(d) a combination consisting of 0.04% triglyceride, 0.08% glycerol, and 4% albumin;
(e) a combination consisting of 0.01% triglyceride, 4% dextran, and 0.8% albumin;
(f) a combination consisting of 4% glutamic acid, 2% propylene glycol, and 0.04% dextran;
(g) a combination consisting of 1% glutamic acid, 4% albumin, and 0.8% dextran; and
(h) a combination consisting of 0.4% glutamic acid, 0.4% albumin, and 4% gelatin.