US 11,872,304 B2
Topical composition
Masato Shigeyama, Seki (JP); Toshiya Nagiri, Naruto (JP); Yuki Takeuchi, Naruto (JP); Yu Mima, Naruto (JP); Katsunori Shirai, Naruto (JP); and Toshimitsu Terao, Naruto (JP)
Assigned to JINNO INSTITUTE, Nagoya (JP); and OTSUKA PHARMACEUTICAL FACTORY, INC., Naruto (JP)
Appl. No. 17/059,534
Filed by JINNO INSTITUTE, Nagoya (JP); and OTSUKA PHARMACEUTICAL FACTORY, INC., Naruto (JP)
PCT Filed May 29, 2019, PCT No. PCT/JP2019/021182
§ 371(c)(1), (2) Date Nov. 30, 2020,
PCT Pub. No. WO2019/230750, PCT Pub. Date Dec. 5, 2019.
Claims priority of application No. 2018-102152 (JP), filed on May 29, 2018.
Prior Publication US 2021/0205210 A1, Jul. 8, 2021
Int. Cl. A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 33/30 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/38 (2006.01)
CPC A61K 9/0014 (2013.01) [A61K 9/06 (2013.01); A61K 33/30 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/38 (2013.01)] 16 Claims
 
1. A topical composition comprising:
(A) 30% to 60% by weight of zinc chloride;
(B) inorganic powder;
(C) additive; and
(D) solvent,
wherein the component (B) comprises silicon dioxide, and
wherein the component (C) is selected from the group consisting of:
(c1) a cellulous derivative in which a hydroxyl group of cellulose is substituted with a substituent selected from the group consisting of —OR1 group, —OR2OH group, —OR3OR4 group, and —OCOR5 group, wherein R1 represents an alkyl group having 1 to 3 carbon atoms, R2 represents an alkylene group having 2 to 3 carbon atoms, R3 represents an alkylene group having 1 to 3 carbon atoms, R4 represents an alkyl group having 1 to 3 carbon atoms, and R5 represents an organic group,
(c2) a polyvinyl-type alcohol selected from the group consisting of polyvinyl alcohol and a derivative thereof, and
(c3) polyoxyethylene polyoxypropylene glycol, and
wherein a weight ratio of the component (B) is 9 parts by weight to 60 parts by weight based on 100 parts by weight of the component (A), and
a weight ratio of the component (C) is 0.1 parts by weight to 13 parts by weight based on 100 parts by weight of the component (A).