US 11,872,259 B2
Processes and systems for converting cannabinoids into cannabinoid derivatives and isolating the same
Armand J. Noel, Tempe, AZ (US)
Assigned to Super Critical IP, LLC, Phoenix, AZ (US)
Filed by Armand J. Noel, Tempe, AZ (US)
Filed on Jul. 20, 2022, as Appl. No. 17/813,716.
Claims priority of provisional application 63/227,875, filed on Jul. 30, 2021.
Claims priority of provisional application 63/227,542, filed on Jul. 30, 2021.
Prior Publication US 2023/0032547 A1, Feb. 2, 2023
Int. Cl. C07C 37/00 (2006.01); C07C 37/74 (2006.01); C07C 37/84 (2006.01); A61K 36/28 (2006.01); A61K 36/185 (2006.01); A61K 31/05 (2006.01); A61K 31/352 (2006.01); C07D 311/80 (2006.01)
CPC A61K 36/28 (2013.01) [A61K 31/05 (2013.01); A61K 31/352 (2013.01); A61K 36/185 (2013.01); C07C 37/003 (2013.01); C07C 37/74 (2013.01); C07C 37/84 (2013.01); C07D 311/80 (2013.01); A61K 2236/35 (2013.01); A61K 2236/37 (2013.01); A61K 2236/51 (2013.01); A61K 2236/53 (2013.01); C07B 2200/13 (2013.01); C07C 2601/16 (2017.05)] 94 Claims
 
1. A process of converting a cannabinoid into a purified cannabinoid derivative, said process comprising:
(a) providing a starting composition comprising a cannabinoid;
(b) providing a solvent comprising a C9-C11 non-aromatic hydrocarbon;
(c) introducing said starting composition and said solvent to a conversion reactor;
(d) operating said conversion reactor at effective reaction conditions to chemically convert said cannabinoid to a cannabinoid derivative at a cannabinoid conversion selected from about 10% to about 90%, thereby generating a reaction mixture containing unreacted cannabinoid;
(e) conveying said reaction mixture to a crystallization unit;
(f) within said crystallization unit, cooling said reaction mixture from a first temperature to a second temperature that is lower than said first temperature, to precipitate at least about 50% of said unreacted cannabinoid out of said reaction mixture, thereby generating a mother liquor containing said cannabinoid derivative; and
(g) isolating and recovering said cannabinoid derivative from said mother liquor.